Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-11-20
1989-11-14
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540227, 540222, C07D50136, A61K 31545
Patent
active
048807982
ABSTRACT:
The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.
The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring, as substitutents at the 3-position of the cephem skeleton, and of groups containing a carboxyl and hydroxy substituted phenylmethyloxyimino moiety, particularly a (carboxy substituted catechol)methyloxyimino moiety, as substituents at the 7-position of the cephem skeleton.
The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.
REFERENCES:
patent: 4103085 (1978-07-01), Naito et al.
patent: 4104469 (1978-08-01), Naito et al.
patent: 4151352 (1979-04-01), Naito et al.
patent: 4278793 (1981-07-01), Durkheimer et al.
patent: 4316024 (1982-02-01), Iimura et al.
patent: 4331666 (1982-05-01), Nannini et al.
patent: 4436912 (1984-03-01), Wheeler
patent: 4500526 (1985-02-01), Imae et al.
patent: 4526977 (1985-07-01), Commons et al.
patent: 4547494 (1985-10-01), Oine et al.
patent: 4576956 (1986-03-01), Makisumi
patent: 4587333 (1986-05-01), Ono et al.
patent: 4594417 (1986-06-01), Yang
patent: 4600773 (1986-07-01), Engel
patent: 4604457 (1986-08-01), Torii et al.
patent: 4609654 (1986-09-01), Labeeuw et al.
patent: 4621081 (1986-11-01), O'Callaghan et al.
J. Antibiotics 36; 532, 1983, T. Nakagome et al.
J. Antibiotics 37; 532, 1984, T. Kamiya et al.
J. Antibiotics 30; 1236, 1986, M. Arimoto et al.
J. Antibiotics 39; 1243, 1986, M. Arimoto et al.
Chem. Abstracts 102:113169e.
Dunn, J. Antimicrob Chemotheraph (1982) 10 Suppl. C, pp. 1-10.
Naito et al., "Cephalosporins III," 30 Journal of Antibiotics 705 (9/77), (Aug. 1983).
Alpegian et al., Cepholosporins VI, 36 Journal of Antibiotics pp. 1013-1019.
Chemical Abstracts, vol. 103, 1985, Abstract No. 37281p.
Chemical Abstracts, vol. 100, 1984, Abstract No. 22505d.
Chemical Abstracts, vol. 102, 1985, Abstract No. 6056u.
Chemical Abstracts, vol. 102, 1985, Abstract No. 24539z.
Kato Kazuo
Mochida Ei
Mochizuki Hidenori
Murakami Kimihiro
Mochida Pharmaceutical Co. Ltd.
Rizzo Nicholas S.
LandOfFree
Cephalosporin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cephalosporin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1853033