Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1986-01-17

1989-02-28

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540222, C07D50136, A61K 31545

Patent

active

048087114

ABSTRACT:
There is disclosed a novel .beta.-lactam antibiotics represented by the formula: ##STR1## wherein A is a group represented by the formulae -NHCO--, --NHCONHCO--, --NHCOCH.dbd.CH-- or ##STR2## where R.sub.6 is a hydrogen atom or a lower alkyl group; R.sub.1 and R.sub.2 are independently a hydrogen atom or a protective group; R.sub.3 is a hydrogen atom or a methoxy group; X is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a halogen atom, a lower alkoxy group or a nitro group; n is an integer of 1 or 2; Y is a group represented by the formulae: ##STR3## provided that a carbon atom which is bonded by a carboxyl group being bonded to nitrogen atom; M is a hydrogen atom, a protective group or an easily hydrolyzable group in a human body; R.sub.7 is a hydrogen atom, a methyl group a lower alkoxy-methyl group or a group represented by the formula: --CH.sub.2 --T where T is an acyloxy group, a carbamoyloxy group, a quaternary ammonium, a substituted or unsubstituted heterocyclic ring or a formula: --S--R.sub.8 where R.sub.8 is an acyl group or a substituted or unsubstituted heterocyclic ring, R.sub.4 and R.sub.5 are each hydrogen atoms or combined with each other to form additional direct bond; Z is a direct bond or a carbonyl group when R.sub.4 and R.sub.5 are hydrogen atoms, or a formula: --O--B-- where the oxygen atom is bonded to nitrogen atom and B is a straight, branched or cyclic alkylene group when R.sub.4 and R.sub.5 are combined with each other to form additional direct bond, or its pharmaceutically acceptable salt.

REFERENCES:
patent: 4200575 (1980-04-01), Numata et al.

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