Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-12-10
2000-07-25
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540224, 540225, C07D50136, A61K 31546
Patent
active
060937122
ABSTRACT:
Provided are cephem derivatives represented by the general formula ##STR1## wherein Ar, R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are as defined in the application. The derivatives are gram-positive antibacterial agents especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus.
REFERENCES:
patent: 5620969 (1997-04-01), Bronson et al.
patent: 5734047 (1998-03-01), Kim
Theodora W. Greene, "Protection for the Carboxyl Group," Protective Groups In Organic Synthesis, Chapter 5, pp. 152-192, John Wiley & Sons, 1981.
I.E. El-Kholy, et al, "Action of Amines and Carbonyl Reagents on 3,5-Diphenyl-4-Pyrone and Its Thio Analogue," J. Heterocyclic Chem., 11, pp. 487-490, 1974.
Bronson Joanne J.
D'Andrea Stanley V.
Hoeft Shelley E.
Hudyma Thomas W.
Kim Oak K.
Berch Mark L.
Bristol-Meyers Squibb Company
Morse David N.
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