Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1989-09-14

1991-11-12

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

540221, 540222, 514201, 514202, C07D50124, A61K 31545

Patent

active

050646494

ABSTRACT:
.beta.-Lactam antibiotics of the formula (Ia) or a pharmaceutically acceptable salt or pharmaceutically acceptable in vivo hydrolysable ester thereof are disclosed: ##STR1## wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is a acyl group, in particular that of an antibacterially active cephalosporin; CO.sub.2 R.sup.6 is carboxy group or a carboxylate anion; R.sup.4 is a butenolide or butanolide ring, optionally substituted by one or two alkyl, dialkylamino, alkoxy, hydroxy or aryl groups, which may be the same or different, or, wherein two adjacent carbon atoms which are available for substitution define the common bond of an aromatic fused bicyclic system; X is S, SO, SO.sub.2, O or CH.sub.2 ; and the dashed line adjacent to R.sup.4 represents an optional double bond. Processes for the preparation of compounds together with intermediates for use therein are disclosed.

REFERENCES:
patent: 4870168 (1989-09-01), Baker et al.
Chemical Abstracts, vol. 113, 114942h (1990).

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