Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1978-02-14

1983-04-19

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 16, 544 28, C07D50120, A61K 31545

Patent

active

043805418

ABSTRACT:
Novel 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporanic acid derivatives of the formula: ##STR1## wherein R.sup.1 NH is an amino group which may optionally be protected, R.sup.2 is a halogen atom or a hydroxyl, thiol or amino group which may optionally be substituted; COOR is a carboxyl group which may optionally be esterified, and pharmaceutically acceptable salts thereof, have excellent antimicrobial activity against a broad spectrum of microorganisms including Gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae, Citrobacter freundii. Thus, these compounds may be used as antibacterial agents for therapeutic purposes.

REFERENCES:
patent: 3962227 (1976-06-01), Chauvette
patent: 3997528 (1976-12-01), Yoshioka et al.
patent: 4007176 (1977-02-01), Berger et al.
patent: 4020058 (1977-04-01), Cocker et al.
patent: 4033950 (1977-07-01), Cook et al.
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4132789 (1979-01-01), Nomura et al.
patent: 4197298 (1980-04-01), Ochiai et al.
JACS, vol. 96 4986, (1974).
Helv Chim Acta, vol. 57 1919, (1974).
Helv Chim Acta, vol. 58 2437, (1975).

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