Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1983-03-31
1985-05-14
Coughlan, Jr., Paul M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544 26, 544 30, C07D50128
Patent
active
045173613
ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula -SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.
REFERENCES:
patent: 3557104 (1971-01-01), Bickel et al.
patent: 4012379 (1977-03-01), Numata et al.
Minamida Isao
Miyawaki Toshio
Numata Mitsuo
Shiraishi Mitsuru
Yamaoka Masayoshi
Coughlan, Jr. Paul M.
Takeda Chemical Industries Ltd.
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