Cephalosporin derivative and pharmaceutical composition

Details Cephalosporin derivative and pharmaceutical composition Cephalosporin derivative and pharmaceutical composition

1984-07-11

1986-04-08

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 21, 544 27, C07D50136, A61K 31545

Patent

active

045813531

ABSTRACT:
A cephalosporin derivative of the formula ##STR1## wherein R is a hydrogen atom, a lower alkyl group which may have been substituted or a carbamoyl group which may have been substituted; R.sub.1 is hydrogen atom or a methoxy group; R.sub.2 is a hydrogen atom, an acyloxy group, or a nitrogen-containing 5-membered heterocyclic thio group which may have been substituted; R.sub.3 is a free amino group or an amino group having a protective group; and R.sub.4 is a free carboxy group or a carboxy group having a protective group or the salts thereof.
The compound of this invention has an excellent antibacterial activity against gram negative bacteria and gram positive bacteria.

REFERENCES:
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4440766 (1981-04-01), Kamiya et al.

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