Cephalosporin deoxygenation process

Details Cephalosporin deoxygenation process Cephalosporin deoxygenation process

1984-09-21

1987-09-22

Daus, Jr., Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, 540222, 540225, 540226, 540227, 540228, 540229, 540230, 2041577, C07D50120, C07D50158

Patent

active

046956271

ABSTRACT:
A process for the preparation of 7.beta.-acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70.degree. C. to 0.degree. C. in an inert organic solvent phosphorus pentachloride with a cephalosporin compound in the presence of an olefinic compound having at least one carbon-carbon double bond having not more than three hydrogen atoms attached thereto capable of removing chlorine at least in part by addition to a carbon-carbon double bond.

REFERENCES:
patent: 4044022 (1977-08-01), Hatfield
patent: 4223133 (1980-09-01), Bunnell
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4266049 (1981-05-01), Bonjouklian
patent: 4308380 (1981-12-01), Kamiya et al.

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