Cephalosporin compounds and processes for preparing thereof

Details Cephalosporin compounds and processes for preparing thereof Cephalosporin compounds and processes for preparing thereof

1994-06-07

1996-11-05

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50138

Patent

active

055719090

ABSTRACT:
Quaternary ammoniocephalosporins of formula(I) wherein Q.dbd.CH or N, P.dbd.hydroxylated amine or hydroxylated heterocyclylamines including N-methyl-bis(2-hydroxyethyl)amine, rac-3,4-trans-dihydroxy-1-methylpyrrolidine, (3S, 4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, meso-3,4-dihydorcy-1-methylpyrrolidine, (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxy-1-methylpiperidine, or tropine, and preparation methods are disclosed. ##STR1##

REFERENCES:
patent: 5010188 (1991-04-01), Yamauchi et al.
patent: 5366970 (1994-11-01), Sakine et al.
Drugs of the Future, vol. 13(4), pp. 369-371 (1988).
Drugs of the Future, vol. 13(10), pp. 805-808 (corresponding to DE Pat. No. 3,307,550).
Synthesis and Structure-Activity Relationships of a New Series of Cephalosporins, BMY-28142 and Related Compounds, The Journal of Antibiotics, 39(8), pp. 1092-1107.

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