Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-05-27
1990-07-24
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514204, 514206, 514207, 540222, 540225, 540227, 540228, A61K 31545, C07D50120
Patent
active
049435671
ABSTRACT:
Cephalosporin compounds represented by the general formula (I): ##STR1## wherein R.sup.1 and R.sup.5 independently represent a hydrogen atom or a protective group for an amino group; R.sup.2 represents an alkyl group or a cycloalkyl group; R.sup.3 represents a hydrogen atom, a lower alkenyl group, an alkanoyloxymethyl group, a carbamoyloxymethyl group, a heterocyclic thiomethyl group or a heterocyclic methyl group; R.sup.4 represents a hydrogen atom or an ester residue; and X represents CH or a nitrogen atom and pharmacologically acceptable addition salts thereof, intermediate compounds used in the synthesis process of these compounds, production methods of these compounds and pharmaceutical compositions containing these compounds.
Said compounds or addition salts thereof exhibit noticeable antibacterial activities even on Pseudomonas aeruginosa, on which known cephalosporin compounds do not exhibit antibacterial activities, and moreover, work well against ordinary Gram-positive bacteria and Gram-negative bacteria.
REFERENCES:
patent: 4370326 (1983-01-01), Takaya et al.
patent: 4372952 (1983-02-01), Takaya et al.
patent: 4487767 (1984-12-01), Takaya et al.
Hatano Satoru
Kakeya Nobuharu
Kamiya Syouzi
Kasai Masayasu
Kitao Kazuhiko
Kyoto Pharmaceutical Industries, Ltd.
Rizzo Nicholas S.
Rozycki Andrew G.
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