Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2008-07-15
2008-07-15
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S047000, C536S023200
Reexamination Certificate
active
11032090
ABSTRACT:
Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression inE. coli.
REFERENCES:
patent: 5192678 (1993-03-01), Iwami et al.
patent: 5320948 (1994-06-01), Iwami et al.
patent: 5336613 (1994-08-01), Niwa et al.
patent: 5457032 (1995-10-01), Quax et al.
patent: 5677141 (1997-10-01), Isogai et al.
patent: 5695978 (1997-12-01), Quax
patent: 5804429 (1998-09-01), Niwa et al.
patent: 5891703 (1999-04-01), Van Der Laan et al.
patent: 5919648 (1999-07-01), Burr et al.
patent: 6303302 (2001-10-01), Rupp et al.
patent: 6528300 (2003-03-01), Binder et al.
patent: 2005/0261270 (2005-11-01), Wong et al.
patent: 2006/0292665 (2006-12-01), Sio et al.
patent: 07-222587 (1995-08-01), None
patent: 08-098686 (1996-04-01), None
patent: 08-205864 (1996-08-01), None
patent: WO 2005/014821 (2005-02-01), None
Itakura, K., et al., 1984, “Synthesis and use of synthetic oligonucleotides”, Annual Review of Biochemistry, vol. 53, pp. 323-356.
Aramori, I., et al., 1991, “Cloning and nucleotide sequencing of new glutaryl 7-ACA and cephalosporin C acylase genes from Pseudomonas strains”, Journal of Fermentation and Bioengineering, vol. 72, No. 4, pp. 232-243.
Ishii, Y., et al., 1995, “High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176”, European Journal of Biochemistry, vol. 230, pp. 773-778.
Otten, L., et al., 2002, “Altering the substrate specificity of cephalosporin C acylase by directed evolution of the β-subunit”, The Journal of Biological Chemistry, vol. 277, No. 44, pp. 42121-42127.
Cabri Walter
Cucchetti Eugenio
Molla Gianluca
Pilone Mirella
Pollegioni Loredano
Antibioticos S.p.A.
Moore William W.
Nashed Nashaat T.
Rothwell Figg Ernst & Manbeck P.C.
LandOfFree
Cephalosporin C acylases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cephalosporin C acylases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin C acylases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3904830