Cephalosporin C acylase

Details Cephalosporin C acylase Cephalosporin C acylase

1992-08-26

1994-06-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

536 232, 435 691, 435 712, 4352523, 43525233, 4353201, 4351723, 935 14, 935 29, 935 56, 935 72, 935 73, C12P 3500, C12P 2102

Patent

active

053209486

ABSTRACT:
A cephalosporin C acylase from Pseudomonas diminuta N-176 is characterized by its ability to catalyze the conversion of cephalosporin C, glutaryl 7-ACA, adipyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin, N-benzoylcephalosporin C and cephalothin into 7-aminocephalosporanic acid. The enzyme contains an .alpha.-subunit having a molecular weight of 26 kDA and a .beta.-subunit having a molecular weight of 58 kDa. A method for the recombinant production of the present cephalosporin C acylase in Escherichia coli is provided.

REFERENCES:
Matsuda et al. "Cloning and Characterization of the Genes for Two Distinct Cephalosporin Acylases from a Pseudomonas Strain". J. Bacteriology vol. 167(12) 5815-5820 (Dec. 1987).

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