Cephalosporin C acylase

Details Cephalosporin C acylase Cephalosporin C acylase

1991-08-20

1993-03-09

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 435 51, 4351723, 4352523, 43525233, 4353201, 935 14, 935 29, 935 56, 935 73, 536 232, C12N 980

Patent

active

051926784

ABSTRACT:
A cephalosporin C acylase from Pseudomonas diminuta N-176 is disclosed as well as the recombinant production of this enzyme in E. coli. The enzyme is characterized by the ability to catalyze the conversion of cephalosporin C, gultaryl 7-ACA, apidyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin C, N-benzoylcephalosporin C, and cephalothin into 7-aminocephalosporanic acid and is composed of an .alpha.-subunit with a molecular weight of 26,000 daltons and a .beta.-subunit with a molecular weight of 58,000 daltons.

REFERENCES:
Matsuda, A. et al "Cloning and Characterization of the Genes for two Distinct Cephalosporin Acylases from a Pseudomonas Strain" J. Bacteriology vol. 169(12)5815-5820 (Dec. 1987).

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