Cephalosporin betaines

Details Cephalosporin betaines Cephalosporin betaines

1981-09-08

1983-08-02

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, A61K 31545, C07D50146

Patent

active

043966195

ABSTRACT:
Broad spectrum cephalosporin betaine antibiotics represented by the formula ##STR1## wherein R' is a heterocyclic ring, e.g. 2-aminothiazol-4-yl, 2-amino-1,3,5-thiadiazol-4-yl, or 2-aminopyridin-6-yl; R" is C.sub.1 -C.sub.4 alkyl, especially methyl, a substituted carbamoyl group, or a carboxy-substituted alkyl or cycloalkyl group; and R.sub.1 is isoquinolinium or a substituted isoquinolinium group are provided. Compounds wherein R.sub.1 is isoquinolinium are preferred especially syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(isoquinolinium- 2-ylmethyl)-3-cephem-4-carboxylate. Pharmaceutical formulations and a method for treating infectious diseases comprising the use of the antibiotics are described.

REFERENCES:
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4152432 (1979-05-01), Heymes et al.
patent: 4160830 (1979-07-01), Morimoto et al.
patent: 4200575 (1980-04-01), Numata et al.
patent: 4260747 (1981-04-01), Heymes et al.
patent: 4264595 (1981-04-01), Numata et al.
patent: 4278793 (1981-07-01), Durckheimer et al.

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