Cephalosporin antibiotics

Details Cephalosporin antibiotics Cephalosporin antibiotics

1980-03-21

1982-02-09

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 25, A61K 31545, C07D50156

Patent

active

043150055

ABSTRACT:
Cephalosporin antibiotics of general formula ##STR1## (wherein R.sup.1 and R.sup.b, which may be the same or different, each represent a C.sub.1-2 alkyl group, or together with the carbon atom to which they are attached form a C.sub.3-6 cycloalkylidene group and Y.sup..sym. represents a 1-carbamoylmethylpyridinium group) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms.
Particularly effective compounds of formula (I) are (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetami do]-3-[(1-carbamoylmethylpyridinium-4-yl)thiomethyl]ceph-3-em-4-carboxylate and (6R,7R)-[(Z)-2-(2-aminothiazol-4-yl)-2-[(1-carboxycyclobut-1-oxyimino)acet amido]-3-[(1-carbamoylmethylpyridinium-4-yl)thiomethyl]-ceph-3-em-4-carboxy late. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I), compositions containing the antibiotic compounds of the invention and processes for the preparation of the antibiotics.

REFERENCES:
patent: 4033950 (1977-07-01), Cook et al.
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4103084 (1978-07-01), Bradshaw et al.
patent: 4144392 (1979-03-01), Bradshaw et al.
patent: 4152432 (1979-05-01), Heymes et al.
patent: 4166115 (1979-08-01), Takaya et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
Tsuchiya et al., Antimicrobial Agents and Chemotherapy 14(4), 557-568 (1978).
Numata et al., J. Antibiotics XXXI (12), 1262-1271 (1978).
Heymes et al., C. R. Acad. Sc., 248, 1847 (1977).
Ochiai et al., Chem. Pharm. Bull. 25(11), 3115-3119 (1977).
Heymes et al., Tetrahedron 34, 2233-2243 (1978).
Hamilton-Miller et al., J. Antimicrobial Chemistry 4, 437-444 (1978).

Affiliated with

Also associated with

Rating

Cephalosporin antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cephalosporin antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1260621