Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1981-07-21
1985-03-12
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 24, 544 25, 544 26, C07D50136, A61K 31545
Patent
active
045044775
ABSTRACT:
Cephalosporin antibiotics of general formula ##STR1## (wherein Y.sup..sym. represents a C-attached 1-C.sub.1-4 alkylpyridinium group) exhibit broad spectrum antibiotic activity with unusually high activity against strains of Pseudomonas organisms as well as high activity against various members of the Enterobacteriaceae. The invention also includes the non-toxic salts, non-toxic metabolically labile esters and 1-oxides of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.
REFERENCES:
patent: 4144392 (1979-03-01), Bradshaw et al.
patent: 4237128 (1980-12-01), Cimarusti et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4315005 (1982-02-01), Ayas et al.
patent: 4394503 (1983-07-01), Kamachi et al.
Ayres Barry E.
Livermore David G. H.
Newall Christopher E.
O'Callaghan Cynthia H.
Weir Niall G.
Glaxo Group Limited
Rizzo Nicholas S.
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