Cephalosporanic acid derivatives

Details Cephalosporanic acid derivatives Cephalosporanic acid derivatives

1982-04-12

1983-09-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50136, A61K 31545

Patent

active

044043767

ABSTRACT:
7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R.sub.2 is selected from the group hydrogen, amino, C.sub.1 to C.sub.6 alkylamino and di-C.sub.1 to C.sub.6 alkylamino and R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group hydrogen, hydroxy, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl, and R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 taken together are the moiety --CH.sub.2 (CH.sub.2).sub.2 CH.sub.2 --.

REFERENCES:
patent: 4064122 (1977-12-01), Ishimaru et al.
patent: 4113944 (1978-09-01), Kai et al.
patent: 4183925 (1980-01-01), Baxter et al.
patent: 4334062 (1982-06-01), Curran
patent: 4336375 (1982-06-01), Boothe et al.
patent: 4338452 (1982-07-01), Katner et al.

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