Cephalosporanic acid derivatives

Details Cephalosporanic acid derivatives Cephalosporanic acid derivatives

1980-10-24

1982-06-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 27, C07D50118

Patent

active

043340628

ABSTRACT:
7-Acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R.sub.2 is selected from the group hydrogen, amino, C.sub.1 to C.sub.6 alkylamino and di-C.sub.1 to C.sub.6 alkylamino and R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group hydrogen, hydroxy, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl and R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 taken together are the moiety --CH.sub.2 (CH.sub.2).sub.2 CH.sub.2 --, and the pharmaceutically acceptable non-toxic salts thereof.

REFERENCES:
patent: 4064122 (1977-12-01), Ishimaru et al.
patent: 4113944 (1978-09-01), Kai et al.
patent: 4183925 (1980-01-01), Baxter et al.

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