Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-06-27
2006-06-27
Kerr, Kathleen M. (Department: 1656)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C514S013800, C514S014800, C530S326000, C530S412000, C435S243000
Reexamination Certificate
active
07067112
ABSTRACT:
The invention relates to compounds of the formula Iin-line-formulae description="In-line Formulae" end="lead"?AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I)in-line-formulae description="In-line Formulae" end="tail"?in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings:a) w is Gly or Ala; x is Aib and y and z are Iva;b) w is Gly; x, y and z are Iva;c) w is Gly; x and z are Aib and y is Iva;d) w is Gly; x, y and z are Aib; ore) w is Gly; x and y are Aib and z is Iva;or of the formula IIin-line-formulae description="In-line Formulae" end="lead"?AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, (II)in-line-formulae description="In-line Formulae" end="tail"?wherein x is Hyp or Pro, which are synthesized byAcremonium tubakiiFH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
REFERENCES:
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Hofmann Joachim
Kurz Michael
Schiell Matthias
Vertesy Laszlo
Finnegan, Henderson Farabow, Garrett and Dunner L.L.P.
Kam Chih-Min
Kerr Kathleen M.
Sanofi-Aventis Deutschland GmbH
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