Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-05-03
2011-05-03
Hutson, Richard G (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S183000
Reexamination Certificate
active
07935789
ABSTRACT:
The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeastSchizosaccharomyces pombe, and a homologue or paralogue thereof having a regulatory activity of chromosome segregation; and DNAs encoding them; as a factor ensuring the retention of unidirection and cohesion in sister centromere at meiosis I in cooperation with cohesin. To elucidate the proteins protecting Rec8 during anaphase, the present inventor screened in fission yeast genes for a gene that inhibits mitotic growth and prevents sister chromatid from the separation at anaphase, when co-expressed with Rec8. In this approach, meiosis-specific protein Sgo1 that protects (Shugo) centromeric Rec8 from the degradation at anaphase I was identified. Further, a budding yeast Sgo1 homologue and a fission yeast mitotic paralogue Sgo2 were identified.
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Communication dated Sep. 24, 2009 cited in a corresponding Canadian counterpart application No. 2,547,655.
Hutson Richard G
Japan Science and Technology Agency
Locke Lord Bissell & Liddell LLP
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