Imperforate bowl: centrifugal separators – With means for indicating – inspecting – measuring – signaling...
Reexamination Certificate
2001-11-30
2003-12-02
Cooley, Charles E. (Department: 1723)
Imperforate bowl: centrifugal separators
With means for indicating, inspecting, measuring, signaling...
C494S045000
Reexamination Certificate
active
06656105
ABSTRACT:
FIELD OF INVENTION
The claimed invention relates to a centrifuge for processing blood and blood components and of which the function is based on an effective utilization of blood processing bags of ring type with associated, if required, secondary bags and other accessories. The secondary bags and the other accessories are of standard type within the area of technology and together these and the characteristic ring bags that are necessary for the centrifuge, in accordance with the invention, could be joined to the bag intended for various special blood processing purposes. This bag set, which is completely manufactured of inert plastic material allowing the blood and blood components to be seen, can therefore have different structures and designs depending on which type of blood processing they are intended for, but they are all based on the utilization of the ring bag as a basic component. The intention of the claimed invention is to offer a blood processing centrifuge with its special shape that makes it possible to limit the number of manual handling stages to a minimum, within every type of blood processing operation in which a centrifuging stage is included.
BACKGROUND
Different types of centrifuges intended for processing blood and blood components and also several types of ring bags intended for using in these centrifuges are to be found described in, for example, WO 87/06857, U.S. Pat. Nos. 5,114,396, 5,723,050, WO 97/30715, WO 98/35757. Of the centrifuges described therein it is primarily those that are included in the two latter-named patent documents that purpose-intended ring bags are utilized combined with standard secondary bags. In the blood processing bags that are stated in WO 87/06857 and in U.S. Pat. No. 5,114,396, instead of purpose-intended ring bags a more complicated type of bag is included, which consists of a ring formed blood processing chamber manufactured as one unit with a centrally arranged secondary bag. In U.S. Pat. No. 5,723,050 a further description is given of a ring bag intended for the same purpose which, in turn, is secured in a central assembly cover which, on the one hand, gives a central control of the ring bag and, on the other hand, to give room internally for the required secondary bags. In WO 97/30715 and WO 98/35757 it is indicated that the ring bags which are used during centrifuging are secured in the centrifuge by a number of holes on their periphery intended to be fitted over the pins secured in the centrifuge and which are intended for that purpose. This is all well and good but is not sufficiently good as has been shown during the course of the years. The stresses on the bags inner periphery edges, especially when it is only thin pins holding them in place, can be so excessive that the edges of the bags rupture.
SUMMARY OF THE INVENTION
To solve this problem the centrifuge, in accordance with the invention, has been equipped with a small number of, for example, three to five supports with a little larger diameter, divided at the same height as the intended position for the ring bag's inner periphery onto which the purpose-made guide holes along the ring bag's inner periphery are located. Via the support's greater contact line with the ring bag and by the centrifuge also being equipped with an opening and closing inner lid, which in the closed position clamps the ring bag's inner edge securely along and between the guide holes we have, in an effective way, been able to determine the ring bag's position in the centrifuge rotor and limit the stresses on the ring bag's inner edge. Consequently, the clamping function limits, through its greater contact area, the load on the ring bag's inner edge and prevents it from slipping over or, in some other way, being released from the supports while the centrifuging is activated. Apart from that, in the inner lid, one or several photocells are advantageously arranged which after centrifuging are used for determining when emptying the ring bag shall be interrupted, in other words, when approaching the interface between the desired and the non-desired component.
By placing the previously described supports with less asymmetry and with the ring bags intended guide holes arranged in the same asymmetric way, a prior defined position for the ring bags is obtained automatically. This has several advantages as it is also possible to define the position for the tubes that connect the ring bags in the different bag sets with each respective secondary bag. We, of course, have found that we can utilize the thicker supports for some other purpose than just for holding the ring bags in position in the centrifuge. According to the claimed invention the supports can thus be equipped with built-in clamping instruments in which the different tubes between the ring bag and secondary bags can be arranged and with which the passage through these tubes can be opened and closed. Apart from that these clamp valves can, on condition that there is sufficient electric power via the centrifuge rotor, be combined with a cutting and welding function with which the tube which passes the clamp valve in question can be sealed and cut as soon as the connecting function, which it represents, is no longer needed. Another occasion when it simplifies how the ring bag is to be placed in the centrifuge is when the used bag set contains a cell trap for which there should suitably exist a preferred space in the centrifuge rotor or on its inner lid. A similar cell trap can, for example, be of the type that is described in WO 97/30715, which in principle consists of one on one priorly defined arc in the slightly longer connecting tube in the centrifuge's rotating part.
That it is at all possible to weld requires, as previously indicated, access to electric power in the centrifuge's rotor and this problem has, in accordance with this further variant of the invention, been solved by means of an arranged slip-ring clutch along the centrifuge's rotor axle. Access to the slip-ring clutches that are concentrically arranged around the centrifuge's rotor axle, and by which means access to the electric power in the centrifuge rotor, has also made possible an effective program control of the different functions in the centrifuge.
A further improvement to the blood processing centrifuge, in accordance with the invention, relates to the production of medicinally valuable blood platelet plasma from the concentrate product, which is designated Buffy Coat at blood donor centers. Before the Buffy Coat can be centrifuged, making the blood platelet-rich product accessible, the original material, which is viscous, is diluted with a standard diluting solution. An example of a similar standard diluting solution that is used profusely in this area is generally designated T-Sol. In normal cases the Buffy Coat is available in the form of concentrates from previous extractions of red blood cells and plasma from whole blood. Each concentrate batch of Buffy Coat is, as a rule, too small, even after diluting with the relevant diluting solution, to be worth an individual centrifuging. As ever) similar type of Buffy Coat concentrate is initially available in its own blood processing bag, a decided amount of diluting solution was previously manually added to each of a number of similar blood processing bags and shaken manually until an acceptable mixture resulted, and added together to a larger bag which was centrifuged.
Apart from all manual handling and the related time required, there is a risk that the person who must shake the blood bags receives-neck and shoulder injuries in the long-term.
To be able to also mechanise this blood processing stage we have now, on the one hand, produced a special bag set intended for that purpose and which includes a ring bag, and on the other hand equipped the centrifuge, in accordance with the invention, with a special mixing function. In the design preferred by us of this part of the invention, the mixing function has been built into or made securable to the outer lid
Hällgren Emanuel
Högberg Niclas
Pihlstedt Peter
Butterfield Laura M.
Cooley Charles E.
Gambro Inc.
O'Connor Edna M.
Scull Peter B.
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