Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1995-03-28
1997-04-22
Gitomer, Ralph
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 29, 435243, C12Q 100, C12Q 102, C12N 100
Patent
active
056228198
ABSTRACT:
The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of particles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.
REFERENCES:
patent: 2616619 (1952-11-01), MacLeod
patent: 3450598 (1969-06-01), Welsh et al.
patent: 3580840 (1971-05-01), Uridil
patent: 3717551 (1973-02-01), Bizzini et al.
patent: 3753731 (1973-08-01), Christ
patent: 3821087 (1974-06-01), Knazek et al.
patent: 3843454 (1974-10-01), Weiss
patent: 3865695 (1975-02-01), Massier
patent: 3871961 (1975-03-01), Gianessi
patent: 3883393 (1975-05-01), Knazek et al.
patent: 3928142 (1975-12-01), Smith
patent: 3941662 (1976-03-01), Munder et al.
patent: 3948732 (1976-04-01), Haddad et al.
patent: 3968035 (1976-07-01), Howe
patent: 3997396 (1976-12-01), Delente
patent: 4001090 (1977-01-01), Kalina
patent: 4036693 (1977-07-01), Levine et al.
patent: 4059485 (1977-11-01), Tolbert et al.
patent: 4087327 (1978-05-01), Feder et al.
patent: 4113173 (1978-09-01), Lolachi
patent: 4114802 (1978-09-01), Brown
patent: 4148689 (1979-04-01), Hino et al.
patent: 4166768 (1979-09-01), Tolbert et al.
patent: 4169010 (1979-09-01), Marwil
patent: 4178209 (1979-12-01), Tolbert et al.
patent: 4184916 (1980-01-01), Tolbert et al.
patent: 4184922 (1980-01-01), Knazek et al.
patent: 4189534 (1980-02-01), Levine et al.
patent: 4195131 (1980-03-01), Papas
patent: 4201845 (1980-05-01), Feeder et al.
patent: 4203801 (1980-05-01), Telling et al.
patent: 4220725 (1980-09-01), Knazek et al.
patent: 4225671 (1980-09-01), Puchinger et al.
patent: 4237033 (1980-12-01), Scattergood
patent: 4237218 (1980-12-01), Monthony et al.
patent: 4266032 (1981-05-01), Miller et al.
patent: 4279753 (1981-07-01), Nielson et al.
patent: 4289854 (1981-09-01), Tolbert et al.
patent: 4293654 (1981-10-01), Levine et al.
patent: 4296882 (1981-10-01), Kobayashi
patent: 4308351 (1981-12-01), Leighton et al.
patent: 4335215 (1982-06-01), Tolbert et al.
patent: 4372484 (1983-02-01), Larsson et al.
patent: 4391912 (1983-07-01), Yoshida et al.
patent: 4413058 (1983-11-01), Arcuri et al.
patent: 4425112 (1984-01-01), Ito
patent: 4442206 (1984-04-01), Michaels et al.
patent: 4463019 (1984-07-01), Okuhara et al.
patent: 4537860 (1985-08-01), Tolbert et al.
patent: 4546085 (1985-10-01), Johansson et al.
patent: 4557504 (1985-12-01), Kuhns
patent: 4603109 (1986-07-01), Lillo
patent: 4661455 (1987-04-01), Hubbard
patent: 4683062 (1987-07-01), Krovak et al.
patent: 4693983 (1987-09-01), Davies et al.
patent: 4722902 (1988-02-01), Harm et al.
patent: 4734372 (1988-03-01), Rotman
patent: 4748124 (1988-05-01), Vogler
patent: 4764471 (1988-08-01), Ripka
patent: 4774187 (1988-09-01), Lehmann
patent: 4804628 (1989-02-01), Cracauer et al.
patent: 4833083 (1989-05-01), Saxena
patent: 4833089 (1989-05-01), Kojima et al.
patent: 4837390 (1989-06-01), Reneau
patent: 4839292 (1989-06-01), Cremonese
patent: 4851354 (1989-07-01), Winston et al.
patent: 4874358 (1989-10-01), Brimhall et al.
patent: 4894342 (1990-01-01), Guinn et al.
patent: 4895806 (1990-01-01), Le et al.
patent: 4897359 (1990-01-01), Oakley et al.
patent: 4898718 (1990-02-01), Cardoso
patent: 4908319 (1990-03-01), Smyczek et al.
patent: 4931401 (1990-06-01), Safi
patent: 4937196 (1990-06-01), Wrasidlo et al.
patent: 4939087 (1990-07-01), Van Wie et al.
patent: 5151368 (1992-09-01), Brinhall et al.
patent: 5247613 (1993-09-01), Roubicek
Lindahl, P.E., Principle of a Counter-streaming Centrifuge for the Separation of Particles of Different Sizes, Nature, vol. 161, No. 4095, Apr. 24, 1948, pp. 648-649.
Morton, H., A Survey of Commercially Available Tissue Culture Media, In Vitro, vol. 6, No. 2 (1970).
Sanderson, R.J., et al., Cell Separations by Counterflow Centrifugation, Methods in Cell Biology, vol. 15, Chapter 1, pp. 1-14 (1977).
Clark, J.M. and M.D. Hirtenstein, "Optimizing Culture Conditions for the Production of Animal Cells in Microcarrier Culture," Annals New York Academy of Sciences, pp. 33-45 (1981).
The Scientist, vol. 8, No. 22, p. 16 (Nov. 14, 1994).
Gitomer Ralph
Kinetic Biosystems Inc.
LandOfFree
Centrifugal fermentation process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Centrifugal fermentation process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Centrifugal fermentation process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-340691