Centrally truncated NPY cyclic peptides

Details Centrally truncated NPY cyclic peptides Centrally truncated NPY cyclic peptides

1994-06-22

1996-10-29

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530323, 530321, 530318, C07K 764, A61K 3812

Patent

active

055697429

ABSTRACT:
Centrally truncated NPY cyclic peptide analogs are described which have selective bioactivity for NPY Y1 receptors. Methods are provided for diagnosing physiological disorders manifested by abnormal levels of endogenous Y1 receptors, by means of measuring the amount of a NPY Y1 specific cyclic peptide analog which binds to a biological sample, and by means of administering a radiolabelled NPY Y1 specific cyclic peptide analog to a host subject followed by radiographic imaging. A method is further provided for therapeutic use of the cyclic peptide NPY analogs in clinical treatment of hypotension and anorexia.

REFERENCES:
patent: 5026685 (1991-06-01), Boublik et al.
patent: 5328899 (1994-07-01), Boublik et al.
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