Central nervous system injury treatment with opiate-receptor ant

Details Central nervous system injury treatment with opiate-receptor ant Central nervous system injury treatment with opiate-receptor ant

1990-08-22

1991-06-18

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514285, A61K 31435, A61K 3144

Patent

active

050250183

ABSTRACT:
The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic central nervous system injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antogonistic activity.

REFERENCES:
Chem. Abst.-106-113401G (1987).
Faden et al., "Opiate Antagonist WIN 44,441-3 Stereospecifically Improves Neurologic Recovery after Ischemic Spinal Injury" Neurology, vol. 35, No. 9, pp. 1311-1315, Sep. 1985.
Ward et al., "Multiple Opioid Receptor Profile in Vitro and Activity in Vivo of the Potent Opioid Antagonist WIN 44,441-3", Life Sciences, vol. 33 Sup. I, pp. 303-306, 1983.

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