Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1992-04-14
1994-09-06
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514453, 514468, A61K 3578, A61K 3135, A61K 3134
Patent
active
053446488
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a central nervous system activator and a taste enhancing food additive. More particularly, the present invention relates to a central nervous system activator and a taste enhancing food additive containing a processed product of a plant body of a plant belonging to the family Rutaceae or an extract thereof, or a limonoid.
BACKGROUND ART
Plants belonging to the family Rutaceae, for example, the bark (without pellicle) of the Phellodendron amurense, that is, Phellodendron Bark, or the powder thereof, that is, Phellodendron Bark Powder, have been used in the past as a stomachic. In the past, however, they have not been used for the purpose of activating the central nervous system. The present inventors found that, unexpectedly, the processed product of the plant body or the extract of a plant belonging to the family Rutaceae has an activity to activate the central nervous system.
Further, the present inventors found that the above-mentioned processed product of the plant body of the plant belonging to the family Rutaceae, in particular, the extract thereof, has a remarkable taste enhancing action.
The present invention is based on these discoveries.
SUMMARY OF THE INVENTION
Therefore, the present invention relates to a central nervous system activator comprising a body or a dried product of a plant belonging to Rutaceae, or an extraction product selected from the group consisting of a lower alkane insoluble portion thereof, a lower fatty acid ester extract of the lower alkane insoluble portion, a lower fatty acid ester/halogenated lower alkane soluble portion of the lower fatty acid ester extract, a limonin fraction of the lower fatty acid ester/halogenated lower alkane soluble portion, and an obacunone fraction of the lower fatty acid ester/halogenated lower alkane soluble portion.
Further, the present invention relates to a central nervous system activator comprising a limonoid.
Further, the present invention relates to a taste enhancing food additive by comprising a body or a dried product of a plant belonging to Rutaceae, or an extraction product selected from the group consisting of a lower alkane insoluble portion thereof, a lower fatty acid ester extract of the lower alkane insoluble portion, a lower fatty acid ester/halogenated lower alkane soluble portion of the lower fatty acid ester extract, a limonin fraction of the lower fatty acid ester/halogenated lower alkane soluble portion, and an obacunone fraction of the lower fatty acid ester/halogenated lower alkane soluble portion.
Further, the present invention relates to a taste enhancing food additive characterized by comprising a limonoid.
BEST MODE FOR CARRYING OUT THE INVENTION
The plants belonging to Rutaceae used in the present invention are plants belonging to Phellodendron (for example, Phellodendron amurense Ruprecht), plants belonging to Citrus (for example Citrus limon BUBM. f., Citrus sinensis OSBECK., Citrus paradishi MACF.), plants belonging to Evodia (for example, Evodia rutaecarpa Hook. fil. et THOMSON), and plants belonging to Dictamnus (for example, Dictamnus albus L. subsp. dasycarpus KITAGAWA).
The preferable plants are Phellodendron amurense and its variants (P. amurense Rupr. var. japonicum (Maxim.) ohwi, P. amurense Pupr. var. sachalinense Fr. Schm., P. ammurense Rupr. var. lavallei (Dode) Sprague, etc. ), P. chinense Schneid and its variants (P. chinese Schneid. forma glabrinsculum (Schneid.) Hsiao, P. chinense Schneid. var. omeiense Huang, P. chinense Schneid. var. yunnanense Huang, P. chinense Schneid. var. falcatum Huang, etc.), P. wilsonii Hayata et Kanehira, Evodia rutaecarpa Hook. fil. et Thomson, Dictamnus albus L. subsp. dasycarpus KITAGAWA, etc.
In the present invention, all or a part of the above plant bodies or a mixture thereof may be used as a starting material. The portions of the plant bodies used preferably are the stalk, leaves, fruit or rind, and the bark (in particular the plants of the Phellodendron), the roots (in particular the plants of the Dictam
REFERENCES:
The Merck Index 9th ed. 1976 p. 718, II 5534.
Isolation of Limonin and Obacunone from Phellodendri Cortex . . . -Chloralose-Urethane, Chemical and Pharmaceutical Bulletin, vol. 38, No. 8, Aug. 1990-Keji Wada et al.
Haga Masanobu
Wada Keiji
Iatron Laboratories Inc.
Rollins John W.
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