Cellulose sulfate salt having anti-coagulating action and proces

Details Cellulose sulfate salt having anti-coagulating action and proces Cellulose sulfate salt having anti-coagulating action and proces

1981-11-25

1983-06-21

Clingman, A. Lionel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536118, 536122, C08G 1810

Patent

active

043895239

ABSTRACT:
A cellulose sulfate salt having a heparinic action is provided, which satisfies requirements of 0.8.ltoreq.<<F>>.ltoreq.2.6, <<f.sub.2 >>.gtoreq.<<f.sub.3 >> and <<f.sub.2 >>.gtoreq.<<f.sub.6 >> wherein <<f.sub.2 >>, <<f.sub.3 >> and <<f.sub.6 >> stand for probability of substitution of atoms H in the OH groups bonded to the C.sub.2, C.sub.3 and C.sub.6 positions of the glucopyranose ring unit by sulfuric acid radicals, respectively, and <<F>> stands for the total substitution degree which is the sum of <<f.sub.2 >>, <<f.sub.3 >> and <<f.sub.6 >>. The cellulose sulfate salt is prepared by reacting a cellulose having a crystal form I with an SO.sub.3 /amine or SO.sub.3 /amide complex in an amount of 2 to 4 mole equivalents per glucose unit of the cellulose at -10.degree. C. to 40.degree. C. to form a gelatinous product; adding water to the gelatinous product in an amount 0.1 to 5 times the amount of the starting cellulose used for the reaction; treating the mixture at a high temperature to relatively reduce the values of <<f.sub.6 >> and <<f.sub.3 >> among the values of <<f.sub.2 >>, <<F.sub.3 >> and <<f.sub.6 >>; neutralizing, precipitating and drying the so obtained crude cellulose sulfate; dissolving the crude cellulose sulfate in water again; treating the solution with an adsorbent; and subjecting the treated cellulose sulfate to precipitation, drying, re-dissolution, dialysis, precipitation and then drying.

REFERENCES:
patent: 3528963 (1970-09-01), Reid
patent: 3609377 (1971-09-01), Pettitt et al.
patent: 3624069 (1971-11-01), Schweiger
patent: 3639665 (1972-02-01), Schweiger
patent: 4064342 (1977-12-01), Saika et al.
patent: 4141746 (1979-02-01), Schweiger

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