Cellulose dialysis membrane with improved biocompatibility

Liquid purification or separation – Filter – Material

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21050024, 21050037, B01D 1300

Patent

active

047723939

ABSTRACT:
The invention relates to a dialysis membrane of regenerated cellulose and to a process for its production. Isocyanate prepolymers with an average molecular weight of 300 to 50,000, which are soluble in organic solvents other than solvents reacting with isocyanate groups and dissolving cellulose, are bound chemically at least to one membrane surface of the dialysis membrane. The dialysis membrane of the present invention substantially eliminates the symptoms of leukopenia and complement activation.

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patent: 4280970 (1981-07-01), Kesting
D. E. Chenoweth et al., Kidney International, vol. 24, pp. 764-769 (1983), "Anaphylatoxin Formation During Hemodialysis . . . ".
D. E. Chenoweth, Asaio Journal, vol. 7, pp. 44-49 (1984), "Biocompatibility of Hemodialysis Membranes".
The Condensed Chemical Dictionary, 10th Edition, G. G. Hawley, Von Nostrand Reinhold Co., N.Y., 1981, p. 522.

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