Cellular internalization of pIgR stalk and associated ligands

Details Cellular internalization of pIgR stalk and associated ligands Cellular internalization of pIgR stalk and associated ligands

1997-05-14

2000-03-28

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

530395, 530403, 530380, 4241851, 4241341, A61K 3816, A61K 39385

Patent

active

060428333

ABSTRACT:
Compositions and methods for specific binding to the stalk of a polymeric immunoglobulin receptor (pIgR) of a cell with the proviso that the ligand does not substantially bind to secretory component of pIgR under physiological conditions. The ligand may be targeted to, into, or across the cell and may comprise a biologically active composition.

REFERENCES:
Breitfeld et al., J. Cell Biology 109:475-486 (1989).
Piskurich et al., Journal of Immunology 154:1735-1747 (1995).
Ferkol et al., J. Clin. Invest. 95:493-502 (1995).
Wu et al., J. Biol. Chem. 262:4429-4432 (1987).
Breitfeld et al., Methods in Cell Biology 32:329-337 (1989).
Eiffert et al., Physiol. Chem. 365:1489-1495 (1984).
Solari et al., J. Histochemistry and Cytochemistry 34(1):17-23 (1986).
Ferkol et al., J. Clin. Invest. 92:2394-2400 (Nov. 1993).
Mostov et al., Ann. Rev. Immunol. 12:63-84 (1994).
Mazanec et al., J. Virol. 69(2):1339-1343 (Feb. 1995).
Williams, G., Tibtech 6:36-42 (Feb. 1988).
Hudson, L. et al. (ed), Practical Immunology, 2nd edition, pp. 192-202, 1980.
Solari, R. et al., J. Biol. Chem. 260:1141-1145, Antibodies recognizing differen domains of the polymeric immunoglobulin receptor, 1985.

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