Cellular injury response element and uses thereof

Details Cellular injury response element and uses thereof Cellular injury response element and uses thereof

1996-06-11

1998-06-23

Guzo, David

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, 536 231, 536 241, C12N 500, C12N 1563, C07H 2104

Patent

active

057704309

ABSTRACT:
The present invention provides a vector with a DNA sequence coding for a cellular injury element promoter from nucleotides -74 to -35 of the GADD153 promoter, relative to the start of transcription. The vector includes an origin of replication in operable linkage with a DNA sequence coding for the promoter. Also, a host cell is transfected with the vector and expresses the cellular injury response element promoter.

REFERENCES:
Fawcett et. al.. Physical and functional association between GADD153 and CCAAT-enhancer-binding proteinbeta during cellular stress. J. Biol. Chem. vol.271(24):14285-14289, Jun. 15, 1996.
Sylvester et. al.. Induction of GADD153, a CCAAT/enhcancer binding protein (C/EBP)-related gene, during the acute phase response in rats. J. Biol. Chem.. vol. 269(31):20119-20125, Aug. 5, 1994.

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