Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-08-09
2011-08-09
Whiteman, Brian (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
Reexamination Certificate
active
07994147
ABSTRACT:
This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products.
REFERENCES:
patent: 6228585 (2001-05-01), Dieckgraefe
patent: 6455674 (2002-09-01), Einat et al.
patent: 6555667 (2003-04-01), Einat et al.
patent: 6716432 (2004-04-01), Paton et al.
patent: 7655788 (2010-02-01), Khvorova et al.
patent: 2006/0088836 (2006-04-01), Wohlgemuth et al.
patent: 2006/0240022 (2006-10-01), Klippel-Giese et al.
patent: 99/09049 (1999-02-01), None
patent: 2004/035615 (2004-04-01), None
Inoue et al. Journal of Drug Targeting 2006, vol. 14, No. 7, pp. 448-4550.
Tuschl 2001, siRNA user guidelines, pp. 1-5.
Harborth et al. (2001) J. Cell Science 114:4557-4565.
Holen et al. (2002) Nucleic Acids Res. 30:1757-1766.
U.S. Appl. No. 60/502,050, filed on Sep. 10, 2003.
Abraham, R. T., et al. “TOR signaling: An odyssey from cellular stress to the cell growth machinery.” Current Biology, 15(4): R139-R141 (2005).
Bakker, W. J., et al. “FOXO3a is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2.” Molecular Cell, 28(6): 941-953 (2007).
Brugarolas, J., et al. “Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.” Genes and Development, 18(23): 2893-2904 (2004).
Corradetti, M. N., et al. “The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.” Journal of Biological Chemistry, 280(11): 9769-9772 (2005).
Ellisen, L. W. “Growth control under stress: mTOR regulation through the REDD1-TSC pathway.” Cell Cycle, 4(11): 1498-1500 (2005).
Ellisen, L. W., et al. “REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.” Molecular Cell, 10(5): 995-1005 (2002).
Han, E. S., et al. “The in vivo gene expression signature of oxidative stress.” Physiological Genomics, 34(1): 112-126 (2008).
Schwarzer, R., et al. “REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.” Oncogene, 24(7): 1138-1149 (2005).
Sofer, A., et al. “Regulation of mTOR and cell growth in response to energy stress by REDD1.” Molecular and Cellular Biology, 25(14): 5834-5845 (2005).
Wouters, B. G., et al. “Control of the hypoxic response through regulation of mRNA translation.” Seminars in Cell and Developmental Biology, 16(4-5): 487-501 (2005).
Feit, et al., J. Pat. Trade. Off. Soc., 85:5-21 (2003).
Qiagen Product Guide 2001 pp. 40-51.
Lee et al. Nature Biotechnology 2002, vol. 19, pp. 500-505.
Samuel C Nature Biotechnology 2004, vol. 22, No. 3, pp. 280-282.
Novina et al. Nature medicine Jul. 2002, vol. 8, No. 7, pp. 681-686.
McManus et al. J. Immunol. 2002, vol. 169, pp. 5754-5760.
Kim, T.A., et al., “HIV-1 tat-mediated apoptosis in human brain microvascular endothelial cells,” J. Immunol., 170:2629-2637, (2003).
Elbim, C., et al., “Redox and activation status of monocytes from human immunodeficiency virus-infected patients: relationship with viral load,” J. Virology, 73:4561-4566, 1999.
Finzi, D. et al. “Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy”; [EBSCO Host Research Databases] Science, vol. 278, 12 pgs, 1997.
Emerman, M. et al. “HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cel Biology”; [EBSCO Host Research Databases]Science, vol. 280:p. 1880, 5p.,1998.
Wong, J.K. et al. “Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia”; [EBSCO Host Research Databases] Science, vol. 278:1297, 5p, 1997.
Corbeil, J. et al. “Temporal Gene Regulation During HIV-1 Infection of Human CD4+ T Cells”; Genome Research, 11: 1198-1204 (2001).
Diatchenko, L. et al. “Suppression subtractive hybridization: A method for generating differentially regulated or . . . ”; Proc. Natl. Acad. Sci USA, 93: 6025-6030 (1996).
Geiss, G.K. et al. “Large-Scale Monitoring of Host Cell Gene Expression during HIV-1 Infection Using cDNA Microarrays”; Virology, 266: 8-16 (2000).
Ryo, A. et al. “Serial analysis of gene expression in HIV-1- infected T celllines”;FEBS Letters, 462: 182-186(1999).
Simm, M. et al. “Cloning of differentially expressed genes in an HIV-1 resistant T cell clone by rapid subtraction hybridization, RaSH”; Gene, 269: 93-101 (2001).
Folks, T.M. et al. “Biological and Biochemical Characterization of a Cloned LEU-3-Cell Surviving Infection with the Acquired . . . ”; J. Exp. Med. 164: 280-290 (1986).
Selliah, N. et al. “Cutting Edge: JAK3 Activation and Rescue of T Cells from HIV gp120-Induced Unresponsiveness”; The Journal of Immunology, 160: 5697-5701 (1998).
Scheuring, U.J. et al., “Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells”; AIDS, 13: 167-175 (1999).
Kinoshita, S. et al., “The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells”; Immunity, 6: 235-244 (1997).
Kinoshita, S. et al. “Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells”; Cell, 95: 595-604 (1998).
Cron, R.Q., et al. “NFAT1 Enhances HIV-1 Gene Expression in Primary Human CD4 T Cells”; Clinical Immunology, 94 (3): 179-191 (2000).
Nekhai, S. et al., “Cell Cycle-Dependent Stimulation of the HIV-1 Promoter by Tat-Associated CAK Activator”; Virology, 266: 246-256 (2000).
Liu, R. et al. “Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection”; Cell, 86: 367-377 (1996).
Bushman, F. et al. “New developments in the biology and treatment of HIV”; PNAS, 95(19): 11041-11042 (1998).
Gelezlunas, R. et al. “HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell”; Nature, 410: 834-838 (2001).
Hoxie, J.A. et al. “Persistent Noncytopathic Infection of Normal Human T Lymphocytes with AIDS-Associated Retrovirus”; Science, New Series, 229(4720): 1400-1402 (1985).
LaCasse, R.A et al. “Fusion-Competent Vaccines: Broad Neutralization of Primary Isolates of HIV”; [EBSCO Host Research Databases] Science, 0036-8075, vol. 283:357 6p. 1999.
Perrin, L. et al. “HIV Treatment Failure: Testing for HIV Resistance in Clinical Practice”; [EBSCO Host Research Databases], Science, vol. 280, Issue 5371, p. 1871, 3p, 1998.
Fauci, A.S. “Host factors and the pathogenesis of HIV-induced disease”; Nature, 384(6609): 529-534 (1996).
McMichael, AJ. et al. “Escape of Human Immunodeficiency Virus from Immune Control”; Annual Review of Immunology, 15(1): 271-296 (1997).
Chun, T. et al. “Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy”; Proc. Natl. Acad. Sci. USA, 94: 13193-13197 (1997).
Pantaleo, G. et al. “Immunopathogenesis of HIV Infection”; Annu. Rev. Microbiol., 50:825-54 (1996).
Rowland-Jones, S. et al. “New Insights into Host Factors in HIV-1 Pathogenesis”; Cell, 104: 473-476 (2001).
Nabel, G.J. “Challenges and opportunities for development of an AIDS vaccine”; Nature, 410: 1002-1007 (2001).
Landau, N.R. “HIV Recent advances in AIDS research: genetics, molecular biology and immunology”; Current Opinion in Immunology, 11 :449-450 (1999).
Ameisen, J.C. “Apoptosis subversion: HIV-Nef provides both armor and sword”; Nature Medicine, 7(11): 1181-1182 (2001).
Casella, C.R. et al. “Vpu Increases susceptibility of Human Immunodeficiency Virus Type 1-Infected Cells to Fas Killing”; J
Finkel Terri H.
Yin Jiyi
Dann Dorfman Herrell & Skillman
Netter, Jr. Robert C.
The Children's Hospital of Philadelphia
Whiteman Brian
LandOfFree
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