Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined...
Patent
1994-05-27
1997-04-22
Rollins, John W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
A61K 3512
Patent
active
056227795
ABSTRACT:
The present invention provides a substantially purified cellular factor that can regulate the expression of genes that encode proteins involved in cholesterol metabolism. The invention also provides methods of obtaining the cellular factors of the invention in a substantially purified form. The invention further provides a method of using a cellular factor of the invention to reduce cholesterol levels in a subject having hypercholesterolemia comprising administering a cellular factor to the subject.
REFERENCES:
Everson, Gregory T., "Bile Acid Metabolism and Its Role in Human Cholesterol Balance." Sem. Liver Disease. 12:420-427 (1992).
Vlahcevic, Z.R., et al., "Function and Regulation of Hydroxylases Involved in the Bile Acid Biosynthesis Pathways." Sem. Liver Disease. 12:403-419 (1992).
Havel, Richard J., "Role of Liver in Hyperlipidemia." Sem. Liver Disease. 12:356-363 (1992).
Davis, Roger A. et al., "Bile Acid Synthesis and the Enterohepatic Circulation: Processes Regulating Total-Body Cholesterol Homeostasis." Molecular Genetics of Coronary Heart Disease and Stroke. (ed. Lusis et al., Karger Press). 208-227 (1992).
Davis, Roger A. et al., "Examination of Bile Acid Negative Feedback Regulation in Rats." J. Lipid Research. 29:202-211 (1988).
Davis, Roger A. et al., "Bile Acid Secretion by Cultured Rat Hepatocytes." J. Biol. Chem. 258:3661-3667 (1983).
Davis, Roger A. et al., "Bile Acid Synthesis by Cultured Hepatocytes." J. Biol. Chem. 258:4079-4082 (1983).
Taniguchi, Takahiro et al., "Regulation of Cholesterol 7 .alpha.-Hydroxylase Gene Expression in Hep-G2 Cells." J. Biol. Chem. 269:10071-10078 (1994).
Rollins John W.
San Diego State University Foundation
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