Cellular encapsulation of biologicals for animal and human use

Details Cellular encapsulation of biologicals for animal and human use Cellular encapsulation of biologicals for animal and human use

1987-09-11

1989-08-29

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424 93, 424DIG8, 514 2, 514773, 514783, A01N 6500

Patent

active

048615951

ABSTRACT:
A biological delivery system particularly suited for delivery of protein compounds to animals and humans is disclosed. The system uses a producing microbe itself after suitable treatment by chemical and/or physical means. The product being delivered is contained within the treated microbial cell; it is produced intracellularly by a homologous (native) gene.

REFERENCES:
patent: 4265880 (1981-05-01), Spence et al.
West, A. W., (1984), "Fate of the Insecticidal, Proteinaceous Parasporal Crystal of B. thuringiensis in Soil", Soil Biol. Biochem., 16:357-360.
West, A. W. et al., (1984), "Detection of B. thuringiensis in Soil by Immunofluorescence"; J. of Invertebrate Pathology, 43:150-155.
Arnold, Russell G. (1984) "Microcapsules for New Animal Drugs," Appl. Biochem. Biotechnol., 10:237-243.
Banaker, Umesh V. (1987) "Innovations in Controlled Release," Amer. Pharm. 27:39-42.
Freeman, F. J., Hayward, J. A. and Chapman, D. (1987) "Permeability Studies on Liposomes Formed from Polymerisable Diacetylenic Phospholipids and Their Potential Applications as Drug Delivery Systems," Biochem. Biophys. Acta. 924:341-351.
Friedman, M., Donbrow, M., and Samuelov, Y. (1979) "Placebo Granules as Cores for Timed Release Drug Delivery Systems," J. Pharm. Pharmacol. 31:396-399.

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