Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Reexamination Certificate
2007-04-24
2007-04-24
Strzelecka, Teresa E. (Department: 1637)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
C422S073000, C435S287100, C435S288400, C435S288500
Reexamination Certificate
active
09965644
ABSTRACT:
A cellular diagnostic array has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse, including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, a gradient array having rectangular shaped channels is used to capture cells and readily show the ratio of volume to surface area for the captured cell. The second silicone rubber array provided by the present invention employs an array of wedge shaped pipettes, each of which captures an individual cell. The position of the cell within a wedge is enough to rapidly determine the cell's actual surface area and volume. A third type of cellular diagnostic array according to the present invention employs an array of channels designed to deform a cell to study how well the cell responds to repeated deformations.
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Brody et al. (Biophysical J. (1995) 68(6) 2224-2232).
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Bitensky Mark W.
Derganc Jure
Frank Michael G.
Gabel Christopher V
Yoshida Tatsuro
Nixon & Peabody LLP
Strzelecka Teresa E.
The Trustees of Boston University
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