Cellular compositions and methods of making and using them

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S325000, C435S375000

Reexamination Certificate

active

07625752

ABSTRACT:
The invention relates to cellular compositions comprising hematopoietic cells with the potential or increased potential to form non-hematopoietic cells; methods for producing such cellular compositions; methods for differentiation of cells of cellular compositions of the invention into cells that exhibit morphological, physiological, functional, and/or immunological features of non-hematopoietic cells; and uses of the cellular compositions. The invention also relates to a method for the expansion of hematopoietic stem and progenitor cells.

REFERENCES:
patent: 6387367 (2002-05-01), Davis-Sproul et al.
patent: WO 98/18486 (1998-05-01), None
patent: WO 00/17326 (2000-03-01), None
patent: WO 01/21766 (2001-03-01), None
patent: WO 01/66698 (2001-09-01), None
patent: WO 01/71016 (2001-09-01), None
Aldskogius H et al. 2002. Strategies for repair of the deafferented spinal cord. Brain Res Rev 40: 301-308.
Roskams AJ et al. 2005. Directing stem cells and progenitor cells on the stage of spinal cord injury. Exp Neurol 193: 267-272.
Daley GQ et al. 2003. Realistic prospects for stem cell therapeutics. Hematology 2003: 398-418.
Kirschstein R. 2001. Can stem cells repair a damaged heart? in Stem Cells: scientific progress and future research directions. pp. 87-92.
Tosh D et al. 2002. Conversion of pancreatic cells to hepatocytes. Biochem Soc Trans 30: 51-55.
Castro RF et al. 2002. Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 297: 1299.
Mezey E et al. and Castro RF et al. 2003. “Comment on Failure of bone marrow cells to transdifferentiate into neural cells in vivo”, “Response to Comment on Failure of bone marrow cells to transdifferentiate into neural cells in vivo.” Science 299:1184b,c.
Reinecke H et al. 2002. Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J Mol Cell Cardiol 34: 241-249.
Murry CE et al. 2004. Hematopoietic stem cells do not transdifferentiate into cardiac mycytes in myocardial infarcts. Nature 428: 664-668.
Graf T. 2002. Differentiation plasticity of hematopoietic cells. Blood 99: 3089-3101.
Orkin SH et al. 2002. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol 3: 323-328.
Asahara et al., “Isolation of Putative Progenitor Endothelial Cells for Angiogenesis”, Science (1997); 275: 964-967.
Bergstrom et al., “Promoter-Specific Regulation of MyoD Binding and Signal Transduction Cooperate to Pattern Gene Expression”, Molecular Cell (2002); 9: 587-600.
Bocci et al., “In-vitro evidence of autocrine secretion of vascular endothelial growth factor by endothelial cells from human placental blood vessels”, Molecular Human Reproduction (2001); 7(8): 771-777.
Boiani et al., “Oct4 distribution and level in mouse clones: consequences for pluripotency”, Genes & Development (2002); 16: 1209-1219.
Bortvin et al., “Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei”, Development (2003); 130: 1673-1680.
Buhring et al., “Stem-cell factor receptor (p145(c-kit)) summary report (CD117)”, in Schlosman et al., (eds.), Leucocyte Typing V. Oxford University Press 1995, pp. 1882-1888.
Byrne et al., “Nuclei of Adult Mammalian Somatic Cells Are Directly Reprogrammed to oct-4 Stem Cell Gene Expression by Amphibian Oocytes”, Current Biology (2003); 13: 1206-1213.
Byrne et al., “From intestine to muscle: Nuclear reprogramming through defective cloned embryos”, PNAS (2002); 99(9): 6059-6063.
Carrera et al., “In vivo response of mouse liver to γ-radiation assessed by the comet assay”, Mutation Research (1998); 413: 23-31.
Chao et al., “Sustained expression of human factor VIII in mice using a parvovirus-based vector”, Blood (2000); 95(5): 1594-1599.
Cosenza et al., “Human Brain Parenchymal Microglia Express CD14 and CD45 and are Productively Infected by HIV-1 in HIV-1 Encephalitis”, Brian Pathology (2002); 12: 442-455.
Dao et al., “Reduction in levels of the cyclin-dependent kinase inhibitor p27kip-1coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells”, PNAS (1998); 95: 13006-13011.
Dick, J., “Absence of CD34 on Some Human SCID-Repopulating Cells”, Annals New York Academy of Sciences, pp. 211-219.
Dick et al., “Assay of Human Stem Cells by Repopluation of NOD/SCID Mice”, Stem Cells (1997); 15: 199-207.
Erices et al., “Human Cord Blood-Derived Mesenchymal Stem Cells Home and Survive in the Marrow of Immunodeficient Mice After Systemic Infusion”, Cell Transplantation (2003); 12: 555-561.
Erices et al., “Mesenchymal progenitor cells in human umbilical cord blood”, British Journal of Haematology (2000); 109: 235-242.
Gage et al., “Grafting Genetically Modified Cells to the Brian: Possibilities for the Future”, Neuroscience (1987); 23(3): 795-807.
Goldfarb, M., “Signaling by Fibroblast Growth Factors: The Inside Story”, STKE (2001); 106: PE37.
Gourevitch et al., “Matrix Metalloproteinase Activity Correlates with Blastema Formation in the Regenerating MRL Mouse Ear Hole Model”, Developmental Dynamics (2003); 226: 377-387.
Gurdon et al., “Nuclear reprogramming and stem cell creation”, PNAS (2003); 100: 11819-11822.
Hakuno et al., “Bone Marrow-Derived Regenerated Cardiomyocytes (CMG Cells) Express Functional Adrenergic and Muscarinic Receptors”, Circulation (2002); 105: 380-386.
Hara et al., “Identification of Podocalyxin-like Protein I as a Novel Cell Surface Marker for Hemangioblasts in the Murine Aorta-Gonad-Mesonephros Region”, Immunity (1999); 11:567-578.
Hattori et al., “Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells”, The Journal of Biological Chemistry (2004); 279(17): 17063-17069.
Herger-Katz et al., “The scarless heart and the MRL mouse”, Phil. Trans. R. Soc. Lond. B (2004); 3595: 785-793.
Hill et al., “Screening for Novel Pattern Formation Genes Using Gene Trap Approaches”, Methods in Enzymology (1993); 225: 664-680.
Hwang et al., “Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst”, Science (2004); 303: 1669-1674 (see attachements).
Jiang et al., “Pluripotency of mesenchymal stem cells derived from adult marrow”, Nature (2002); 418: 41-49.
Kormori et al., “Targeted Disruption of Cbfal Results in a Complete Lack of Bone Formation owing to Mutrational Arrest of Osteoblasts”, Cell (1997); 89: 755-764.
Krause et al., “Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell”, Cell (2001); 105: 369-377.
Kuwana et al., “Human circulating CD14+monocytes as a source of progenitors that exhibit mesenchymal cell differentiation”, Journal of Leukocyte Biology (2003); 74: 833-845.
Liu et al., “The MyoD-Inducilbe p204 Protein Overcomes the Inhibition of Myoblast Differentiation by ID Proteins”, Molecular and Cellular Biology (2002); 2893-2905.
Mareschi et al., “Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood”, Haematologica (2001); 86: 1099-1100.
Megeney et al., “Severe cardiomyopathy in mice lacking in dystrophin and MyoD”, PNAS (1999); 96: 220-225.
Meletis et al., “Have the bloody cells gone to our heads?”, The Journal of Cell Biology (2001); 155(5): 699-702.
Mori et al., “DNA base damage generated in vivo in hepatic chromatin of mice upon whole body γ-irradiation”, Int. J. Radiat. Biol. (1993); 64(6): 645-650.
Moroni et al., “Fibroblast Growth Factors and Their Receptors in Hematopoiesis and Hematological Tumors”, Journal of Hematotherapy & St

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cellular compositions and methods of making and using them does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cellular compositions and methods of making and using them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cellular compositions and methods of making and using them will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4149623

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.