Cellular basis of transplant arteriosclerosis in mice

Details Cellular basis of transplant arteriosclerosis in mice Cellular basis of transplant arteriosclerosis in mice

1995-01-24

1997-10-07

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435 1, 424 92, 424569, 600 36, 600 1, C12N 1500, A01N 102, A61N 500, A61F 204

Patent

active

056750625

ABSTRACT:
A mouse model for transplant arteriosclerosis useful for identifying compounds which reduce or prevent such arteriosclerosis, consisting of a mouse engrafted with a histoincompatible artery which exhibits detectable arteriosclerosis within 30 days of transplantation. Also disclosed are therapeutic methods for inhibiting the development of transplant arteriosclerosis in mammalian recipients of allografted organs.

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