Cellular attachment to trans-epithelial appliances

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4352402, 43524023, 4352831, 606 1, 606151, 606167, C12N 500, A01N 102, A61B 1700, A61B 1708

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active

055852670

ABSTRACT:
A trans-epithelial appliance having a hemidesmosome formation-inducing protein composition derived from rat bladder carcinoma cells deposited thereon. This composition stimulates cell attachment and may be either the cell matrix or a soluble factor isolated from the conditioned medium. The appliance will be useful for diminishing inflammation and/or infection at the site of entry of the appliance. The appliance may also be used to stimulate gum junctional epithelium adhesion in the treatment of gingivitis and periodontitis. The composition may be used to maintain tissues ex vivo.

REFERENCES:
patent: 4836884 (1989-06-01), McAuslan
patent: 4963490 (1990-10-01), Churchouse et al.
patent: 5007925 (1991-04-01), Tsilibary et al.
patent: 5256418 (1993-10-01), Kemp et al.
patent: 5266476 (1993-11-01), Sussman et al.
patent: 5278063 (1994-01-01), Hubbell et al.
patent: 5330911 (1994-07-01), Hubbell et al.
patent: 5352668 (1994-10-01), Burgeson et al.
patent: 5385836 (1995-01-01), Kimura et al.
patent: 5415938 (1995-05-01), Cahalan et al.
patent: 5422264 (1995-06-01), Quaranta et al.
patent: 5453278 (1995-09-01), Chan et al.
patent: 5510263 (1996-04-01), Quaranta et al.
patent: 5512474 (1996-04-01), Clapper et al.
Budavari, S. et al. (eds.), The Merck Index, 11th ed., Merck & Co., Inc., Rahway, N.J., p. 544.
Riddelle, K., Dissertation Abstracts International, vol. 55(1), pp. 22-B-23-B.
Langhofer, M., Dissertation Abstracts International, vol. 56 (3), pp. 1199-B-1200-B.
Hopkinson, S. B. et al., Molecular Biology of the Cell, vol. 4(suppl.), abstract #568, p. 97a.
J. Jones, et al. (1991) "A Function for the Integrin .alpha..sub.6 .beta..sub.4 in the Hemidesmosome", Cell Regulation 2:427-438.
Boukamp, et al., "Normal Keratinization in a Spontaneously Immortalized Aneuploid Human Keratinocyte Cell Line", The Journal of Cell Biology, 106: 761-771, Mar. 1988.
Chapman, et al., "Abnormal Expression of Hemidesmosome-Like Structures by Junctional Epidermolysis Bullosa Keratinocytes In Vitro", British Journal of Dermatology, 123:137-144, 1990.
Garrison, et al., "Drosophila Laminin A Chain Sequence, Interspecies Comparison, and Domain Structure of a Major Carboxyl Portion", The Journal of Biological Chemistry, 266:34:22899-22904, Dec. 1991.
Giudice, et al., "Identification of Two Collagen Domains Within the Bullous Pemphigoid Autoantigen, BP180", J. Clin. Invest., 87:734-738, 1991.
Hieda, et al., "Identification of a New Hemidesmosomal Protein, HD1: A Major, High Molecular Mass Component of Isolated Hemidesmosomes", The Journal of Cell Biology, 116:6:1497-1506, 1992.
Hopkinson, et al., "Expression of Hemidesmosomal Plaque Components", J. Cell. Biology. 111: (5.Pt.2) 408a. 1990.
Hopkinson, et al., "Cytoplasmic Domain of the 180-kD Bullous Pemphigoid Antigen, A Hemidesmosomal Component: Molecular and Cell Biologic Characterization", The Journal of Investigative Dermatology, 99:3:264-270, 1992.
Hormia, et al., "The Distribution of Integrin .alpha..sub.6 .beta..sub.4 in Keratinocytes is Modulated by Rat Carcinoma Cells", Meeting of the International Association for Dental Research, Chicago, IL, Feb. 1993 (abstract).
Izumi, et al., "In Vitro Induction of Ornithine Decarboxylase in Urinary Bladder Carcinoma Cells", Cancer Research, 41:405-409, 1981.
Jones, et al., "Intermediate Filament-Plasma Membrane Interactions", Cell Biology, 3:127-132, 1991.
Jones, et al., ".alpha..sub.6 .beta..sub.4 Integrins: Their Role in the Assembly of the Hemidesmosome (HD) and in Signal Transduction", J. Cellular Biochem., 16F:142, Apr. 1992.
Kallunki, et al., "A Truncated Laminin Chain Homologous to the B2 Chain: Structure, Spatial Expression, and Chromosomal Assignment", The Journal of Cell Biology, 119:3:679-693, Nov. 1992.
Klatte, et al., "Immunochemical Characterization of Three Components of the Hemidesmosome and Their Expression in Cultured Epithelial Cells", The Journal of Cell Biology, 109:6:Pt.2:3377-3390, Dec. 1989.
Kurpakus, et al., "Integrins in the Hemidesmosome", J. Cell Biol., 111:(5.Pt.2), 1990.
Kurpakus, et al., "Surface Relocation of Alpha.sub.6 Beta.sub.4 Integrins and Assembly of Hemidesmosomes in an In Vitro Model of Wound Healing", The Journal of Cell Biology, 115:(6):1737-1750, 1991.
Langhofer, et al., "Matrix Signals Transduced by the .alpha..sub.6 .beta..sub.4 Integrin Complex", Mol. Biol. Cell, 3(Suppl.):95a, Sep. 1992.
Langhofer, et al., "The Matrix Secreted by 804G Cells Contains Laminin-Related Components that Participate in Hemidesmosome Assembly In Vitro", Journal of Cell Science, 105:753-764, 1993.
Riddelle, et al., "Characterization of a Novel Cell-Substratum Attachment Device In Cultured Epithelial Cells", J. Cell Biol., 109:4:Pt.2:201a, 1989.
Riddelle, et al., "Hemidesmosomes in Cultured Cells", J. Cell Biol., 111:5:Pt.2:2270, 1990 #408a.
Riddelle, et al., "Formation of Hemidesmosomes In Vitro by a Transformed Rat Bladder Cell Line", The Journal of Cell Biology, 112:1:159-168, 1991.
Riddelle, et al., "Dynamic Aspects of Hemidesmosomes in the Novel Epithelial Cell Line, 804G", J. Cell Biol., 115:3:Pt.2:41a, 1991.
Riddelle, et al., "Hemidesmosomes in the Epithelial Cell Line 804G: Their Fate During Wound Closure, Mitosis and Drug Induced Reorganization of the Cytoskeleton", Journal of Cell Science, 103:475-490, 1992.
Riddelle, et al., "Substrate Attachment is Necessary for the Expression of Hemidesmosomal Proteins in Cultured Cells", Mol. Biol. Cell. 3:Suppl.:70a, 1992.
Rousselle, et al., "Kalinin: An Epithelium-Specific Basement Membrane Adhesion Molecule That is a Component of Anchoring Filaments", Journal of Cell Biology, 114:3:567-576, Aug. 1991.
Rousselle, et al., "Kalinin is More Efficient than Laminin in Promoting Adhesion of Primary Keratinocytes and Some Other Epithelial Cells and Has a Different Requirement for Integrin Receptors", The Journal of Cell Biology, 125:1:205-214, Apr. 1994.
Schwarz, et al., "Desmosomes and Hemidesmosomes: Constitutive Molecular Components", Annu. Rev. Cell Biol., 6:461-491, 1990.
Sonnenberg, et al., "Integrin .alpha..sub.6 /.beta..sub.4 Complex is Located in Hemidesmosomes, Suggesting a Major Role in Epidermal Cell-Basement Membrane Adhesion", The Journal of Cell Biology, 113:(4):907-917, 1991.
Staehelin, "Structure and Function of Intercellular Junctions", Dept. of Mol. Cellular and Developmental Biology, Univ. of Colorado, Boulder, CO, 191-283.
Stepp, et al., ".alpha..sub.6 .beta..sub.4 Integrin Heterodimer is a Component of Hemidesmosomes", Proc. Natl. Acad. Sci. USA, 87:8970-8974, 1990.

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