Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-06-14
2005-06-14
Fredman, Jeffrey (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S320100, C435S252800, C435S174000, C435S183000, C382S129000, C382S133000, C382S153000, C382S173000, C382S286000, C382S291000, C702S019000, C702S022000, C536S022100
Reexamination Certificate
active
06905823
ABSTRACT:
A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue, such as susceptibility or resistance to particular types of drug treatment. Other examples of suitable tissues which can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines).
REFERENCES:
patent: 5665549 (1997-09-01), Pinkel et al.
patent: 5690894 (1997-11-01), Pinkel et al.
patent: 5693610 (1997-12-01), Matsunaga et al.
patent: 5821218 (1998-10-01), Toback et al.
patent: 5843767 (1998-12-01), Beattie
patent: 5856097 (1999-01-01), Pinkel
patent: 5976790 (1999-11-01), Pinkel et al.
patent: 6001621 (1999-12-01), Godowski et al.
patent: 6156522 (2000-12-01), Keay
patent: 6333153 (2001-12-01), Fishel
L. Bubendorf et al., “Tissue-microarray technology (“tissue chip”) for molecular profiling of Prostate cancer progression: Making FISH a high-throughput tool for cancer genetics” The American Journal of Human Genetics, 63(4) 1998, Abstract No. 1.
Forozan et al., “Genome Screening by Comparative Genomic Hybridization”, Trends in Genetics, 13(10):405-409, (Oct. 1997).
M. Heiskanen et al., “High-resolution CGH array analysis reveals unexpected gene amplifications in breast cancer” The American Journal of Human Genetics, 63(4) 1998, Abstract No. 386.
Joos et al., “Mapping of Chromosomal . . . Genomic Hybridization”, Genes Chromosomes and Cancer, 14:267-276, (1995).
Kononen et al., “Tissue Microarrays for high-throughput molecular profiling of tumor specimens,” Nature Medicine, 4(7):844-847 (Jul. 1998).
Leveen et al., “Negative trans-acting Mechanisms controlling Expression of Platelet-derived Growth Factor A and B mRNA in Somatic cel Hybrids,” Experimental Cell Research, 207:283-289, (1989).
Pinkel et al., “High Resolution Analysis of DNA . . to Microarrays”, Nature Genetics, 20:207-211, (1998).
P. Schraml et al., “Tumor tissue arrays for gene amplification detection in multiple different tumor types” The American Journal of Human Genetics, 63(4) 1998, Abstract No. 845.
Barlund Maarit
Kallioniemi Olli-P
Kononen Juha
Müller Uwe Richard
Sauter Guido
Abbott Laboratories
Ali Janann Y.
Atwood Pierce
Chakrabarti Arun
Farrell Kevin M.
LandOfFree
Cellular arrays and methods of detecting and using genetic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cellular arrays and methods of detecting and using genetic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cellular arrays and methods of detecting and using genetic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3512043