Cellular apoptosis susceptibility protein (CSP)

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 235, 536 231, C07K 1447

Patent

active

06072031&

ABSTRACT:
The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents or inhibits apoptosis in the cells.

REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
Reeck et al., "Homology" in proteins and nucleic acids: a terminology muddle and a way out of it, Cell, 50:667, Aug. 1987.
Cohen, J.J., "Apoptis", Immunol. Today 14: 126-130, 1993.
Lowe et al., "p53 is required for radiation-induced apoptosis in mouse thymocytes", Nature 362:847-849, 1993.
Nathan, et al., "Expression of BCL-2 in primary breast cancer and its correlation with tumour pheotype", Ann. Oncol. 5:409-414, 1994.
Brinkmann, et al., "Expression Cloning of cDNAs that Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins", Molec. Med. 1: 206-216, 1995.
Xiao, et al., "CSE1 and CSE2, Two New Genes Required for Accurate Mitotic Chromosome Segregation in Saccharomyces cerevisiae", Mol. Cell. Biol. 13: 4691-4702, 1993.
Brinkmann, et al., "B3 (Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice", Proc. Natl. Acad. Sci. USA 88: 8616-8620, 1991.
Kochi, et al., "DNA Fragmentation and Cytolysis in U937 Cells Treated with Diptheria Toxin or Other Inhibitors of Protein Synthesis", Exp. Cell Res. 208: 296-302, 1993.
Chang, et al., "Internucleosomal DNA Cleavage Precedes Diphtheria Toxin-induced Cytolysis", J. Biol. Chem. 264: 15261-15267, 1989.
Morimoto, et al., "Diphtheria Toxin-and Pseudomonas A Toxin-Mediated Apoptosis", J. Immunol. 149: 2089-2094, 1992.
Tanner et al., "Increased Copy Number at 20q13 in Breast Cancer: Defining the Critical Region and Exclusion of Candidate Genes", Cancer Res. 54, 4257-4260, 1994.
Orkin, Stuart H., M.D., et al., "Report and recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 7, 1995.
Brinkmann et al., "Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1", Proc. Natl. Acad. Sci. USA 92:10427-10431 (1995).
Copy of page from International Search Report showing documents considered to be relevant.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cellular apoptosis susceptibility protein (CSP) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cellular apoptosis susceptibility protein (CSP), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cellular apoptosis susceptibility protein (CSP) will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2214456

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.