Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1996-08-14
1998-12-01
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241361, 4241531, 4241731, 4241751, 5303873, 5303887, 53038885, 5303889, 5303896, 5303891, 5303898, A61K 39395, C07K 1618, C07K 1628, C07K 1644
Patent
active
058434402
ABSTRACT:
Novel bifunctional reagents useful in reducing the biological effect of an undesirable blood-borne agent are provided. The reagents comprise conjugates of a first binding member specific for a blood-borne agent having a detrimental biological activity in a mammalina host, such as a growth factor, coagulation factor, enzyme, toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumorous cell, joined to an second binding member specific for an anchor, where the anchor is a long-lived blood component, including cells, such as a erythrocyte, platelet or endothelial cell and serum proteins, such as albumin, ferritin, or steroid binding proteins. These conjugates find therapeutic use by coupling the agent and the blood component and thereby reducing the biological activity or effective concentration of free agent, modulating the volume of distribution of the agent, targeting the agent to sites of enhanced immune response, or facilitating agent clearance from the bloodstream.
REFERENCES:
Koolwijk et al. Molecular Immunology vol. 28 No. 6 pp. 567-576 1991.
Titus et al. Journal of Immunology 139:9-3153-3158 1987.
Taylor et al. PNAS 88 pp. 3305-3309 1991.
Taylor et al. Journal of Immunology 148:8 pp. 2462-2468 1992 (Apr. 15).
Harris et al. TibTech 1993 (vol. 11) p. 42.
Hjrd et al. Genes and Cancer Ed. Carney & Sikora et al. 1990 p. 183.
Waldmann Science vol. 252 p. 1657, 1991.
Pouletty Christine
Pouletty Philippe
Johnson Nancy A.
RedCell Canada, Inc.
Scheiner Toni R.
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