Cellubrevin homologs

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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4353201, 435325, 435 691, 536 235, 536 2431, C12Q 168, C12N 1563, C12N 1585, C12N 1500, C07H 2104

Patent

active

060602392

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

REFERENCES:
patent: 5650280 (1997-07-01), Stuart et al.
Baumert, et al., "Synaptobrevin: an integral membrane protein of 18 000 daltons present in small synaptic vesicles of rat brain" Embo J 8(2):379-384 (1989).
Ralston, E et al., "Expression of the Synaptic Vesicle Proteins VAMPs/Synaptobrevins 1 and 2 in Non-neural Tissues" J Biol Chem 269:15403-6 (1994).
McMahon, HT et al., "Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein" Nature 364:346-9 (1993).
Galli, et al., "Tetanus Toxin-mediated Cleavage of Cellubrevin Impairs exocytosis of transferrin receptor-containing vesicles in CHO cells" J Cell Biol 125:1015-24 (1994).
Link, E et al., "Cleavage of Cellubrevin by Tetanus Toxin Does Not Affect Fusion of Early Endosomes" J Biol Chem 268:18423-6 (1993).
Bark, IC and Wilson MC, "Regulated vesicular fusion in neurons: Snapping together the details" Proc Natl Acad Sci 91:4621-4624 (1994).
Richter, K et al., "Gene expresion in the embroyonic nervous system of Xenopus laevis" Proc Natl Acad Sci USA 85:8086-90 (1988) (Accession GI 388483).
Sudhof, TC et al., "A synaptic vesicle membrane protein is conserved from mammals to Drosophila" Neuron 2:1475-81 (1989) (Accession GI 433075).

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