Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1997-10-07
2000-08-01
Park, Hankyel
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
424422, 4241331, 4241431, 424 937, 435 71, 435 72, 435 721, 53038822, C12N 500, A61F 1300, G01N 3353, C07K 1600
Patent
active
060965371
ABSTRACT:
Cells suitable for transplantation which have at least two different epitopes on a surface antigen altered prior to transplantation to inhibit rejection of the cells following transplantation into an allogeneic or xenogeneic recipient are disclosed. These cells are more successfully transplanted than cells which have only a single epitope on the surface antigen altered. Preferably, the antigen on the cell surface which is altered is an MHC class I antigen. Two different epitopes on an MHC class I antigen can be altered by contacting the cell with two molecules, such as antibodies or fragments thereof (e.g., F(ab').sub.2 fragments), which bind to two different epitopes on the antigen. Preferred epitopes on human MHC class I antigens to be altered are epitopes recognized by the monoclonal antibodies W6/32 and PT85. Improved methods for transplantation utilizing cells which have at least two different epitopes on a surface antigen altered prior to transplantation are also disclosed.
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Diacrin, Inc.
Mandragouras, Esq. Amy E.
Park Hankyel
Williams Megan E.
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