Cells transformed or transfected with HCMV US2 gene

Details Cells transformed or transfected with HCMV US2 gene Cells transformed or transfected with HCMV US2 gene

1998-03-16

1999-06-01

McKelvey, Terry

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, C12N 510, C12N 1563, C12N 1586

Patent

active

059087803

ABSTRACT:
Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. A recombinant mutant HCMV which fails to down-regulate class I heavy chain expression is described. A method of controlling down-regulation of MHC class I expression in a cytomegalovirus infected cell, a pharmaceutical composition, a vaccine composition,
a method of preventing or reducing susceptibility to acute cytomegalovirus in an individual, and a virus based gene therapy vector are also described.

REFERENCES:
patent: 4058598 (1977-11-01), Stern et al.
patent: 4877612 (1989-10-01), Berger et al.
patent: 4877737 (1989-10-01), Shih et al.
Kollert, Jons A. et al., J. Virology, vol. 65, No. 10, 1991, pp. 5184-5189.
Jones, T.R. et al., J. Virology, vol. 66, No. 4, 1992, pp. 2541-2546.
Chee M.S. et al., Current Topics in Microbiology and Immunology, vol. 154, 1990, pp. 126-169.
Gilbert, M.J. et al., J. Virology, vol. 67, No. 6, 1993, pp. 3461-3469.
Beersma, M.F.C. et al., J. Immunology, vol. 151, No. 9, 1993, pp. 4455-4464.
Jones, T.R. et al., J. Virology, vol. 69, No. 8, 1995, pp. 4830-4841.
Colberg-Poley, A. M. et al., J. Virology, vol. 66, No. 1, 1992, pp. 95-105.
Jones, T. R. et. al., J. Virology, vol. 65, No. 11, 1991, pp. 5860-5872.
Jones, T. R. et. al., J. Virology, vol. 65, No. 4, 1991, pp. 2024-2036.

Affiliated with

Also associated with

Rating

Cells transformed or transfected with HCMV US2 gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cells transformed or transfected with HCMV US2 gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cells transformed or transfected with HCMV US2 gene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-954662