Cells producing stem cell proliferation factor

Details Cells producing stem cell proliferation factor Cells producing stem cell proliferation factor

1994-10-06

1997-07-22

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435 711, 435354, 435372, 435325, 530350, 530351, C12P 2102, C12N 506, C12N 508

Patent

active

056502990

ABSTRACT:
The present invention is directed to an autocrine growth factor. In particular, it relates to the production, purification and uses of stem cell proliferation factor (SCPF). In various cell lines, the protein of the invention exists in two forms, a soluble form and a membrane bound form which is detectable on the surface of a small percentage of human bone marrow cells and stimulates the proliferation of these cells. Therefore, SCPF may have a wide range of applications including but not limited to augmenting the growth of hematopoietic stem cells. Further, removal of the protein by an antibody may be useful in controlling tumor cell growth.

REFERENCES:
Bagwell et al., "Regulation of Tumor Growth by Antibody to a Novel Autocrine Growth Factor," Surg. Formum. 43(0):609-613, Oct. 11-16, 1992.
Bruno et al., "Further Examination of the Effects of Recombinant Cytokines on the Proliferation of Human Megakaryocyte Progenitor Cells," Blood, 77(11):2339-2346, Jun. 1991.
Cicuttini et al., "The Effect of Recombinant Stem Cell Factor (SCF) on Purified CD34-Positive Human Umbilical Cord Blood Progenitor Cells," Growth Factors, 6(1):31-39, 1992.
Goding, "Monoclonal Antibodies: Principles and Practice", 2nd Edition, pp. 59-103 Academic Press, 1986.
Litzow et al., "Proliferative Responses to Interleukin-3 and Granulocyte Colony-Stimulating Factor Distinguish a Minor Subpopulation of CD34-Positive Marrow Progenitors that do not Express CD33 and a Novel Antigen, 7B9," Blood, 77(11):2354-2359, Jun. 1991.
McNiece et al., "Recombinant Human Cell Factor Synergies with GM-CSF, G-CSF, IL-3 and epo to Simulate Human Progenitor Cells of the Myeloid and Erythroid Lineages," Exp. Hematol., 19(3):226-231, Mar. 1991.
Moore et al., "Cytokine Networks Involved in the Regulation of Haemopoietic Stem Cell Proliferation and Differentiation," Ciba Foundation Symposium, 143, 43-61, 1990.
Strauss et al., "Initiation in DNA Synthesis by Colony-Stimulating Factors in Subsets of Human CD34 Positive Marrow Cells," Exp. Hematol, 19(8):734-741, 1991.
Thomas et al., "In Vitro Effects of Recombinant Hemopoietic Growth Factors on Progenitor Cells from Patients with Myelodysplastic Syndromes," Leuk. Res., 15(1):29-36, 1991.
Waldmann, "Monoclonal Antibodies in Diagnosis and Therapy," Science, 252:1657-1662, Jun. 1991.

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