Cells for drug discovery

Details Cells for drug discovery Cells for drug discovery

2006-05-16

2006-05-16

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S325000

Reexamination Certificate

active

07045304

ABSTRACT:
Disclosed herein are compositions and method useful in screening a compound for its interaction and/or effect with a molecular target and/or cellular process.

REFERENCES:
patent: 4980281 (1990-12-01), Housey
patent: 5266464 (1993-11-01), Housey
patent: 5298429 (1994-03-01), Evans et al.
patent: 5580721 (1996-12-01), Brent et al.
patent: 5580722 (1996-12-01), Foulkes et al.
patent: 5688655 (1997-11-01), Housey
patent: 5767075 (1998-06-01), Avruch et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 5877007 (1999-03-01), Housey
patent: 6007988 (1999-12-01), Choo et al.
patent: 6013453 (2000-01-01), Choo et al.
patent: 6140081 (2000-10-01), Barbas
patent: 6140466 (2000-10-01), Barbas et al.
patent: 6303319 (2001-10-01), Rickles
patent: WO 91/18980 (1991-12-01), None
patent: WO 93/06121 (1993-04-01), None
patent: WO 94/08051 (1994-04-01), None
patent: WO 95/12608 (1995-05-01), None
patent: WO 95/19431 (1995-07-01), None
patent: WO 95/30642 (1995-11-01), None
patent: WO 96/30540 (1996-10-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/47656 (1999-09-01), None
patent: WO 00/23464 (2000-04-01), None
patent: WO 00/27878 (2000-05-01), None
patent: WO 00/41566 (2000-07-01), None
patent: WO 00/42219 (2000-07-01), None
Darling et al. A zinc finger homeodomain transcription factor binds specific thyroid hormone response elements'□□Molecular and cellular endocrinology. Mol. and Cell. Endocrin. 1998 vol. 139 No. 1-2, pp. 25-35.
Beerli et al. Toward controlling gene expression at will: specific regulation of the erbB-2/her-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. PNAS 1998 vol. 95 No. 25, pp. 14628-14633.
Scheinman et al. Characterization of Mechanisms involved in transfrepression of NF-kappa B by activated blucocorticoid receptors. Mol. Cell. Biol. vol. 15 No. 2 1995 pp. 943-953.
Kim et al. A novel member of the RING finger family KRIP-a associates with the KRAB-A transcriptional repressor domain of zinc-finger proteins PNAS vol. 93 1996 pp. 15299-15304.
Hall et al. Functional interaciton between the two zinc finger domains of the v-erb A oncoprotein. Cell Growth and Differentiation vol. 3 1992 pp. 207-216.
Beerli et al., “Toward Controlling Gene Expression at Will: Specific Regulation of the erbB-2/HER-2 Promoter by Using Polydactyl Zinc Finger Proteins Constructed From Modular Building Blocks,”Proc. Natl. Acad. Sci. U.S.A. 95; 14628-14633.
Choo et al., “In VivoRepression by a Site-Specific DNA-Binding Protein Designed Against an Oncogenic Sequence,”Nature 372:642-645 (1994).
Darling et al., “A zinc finger homeodomain transcription factor binds specific thyroid hormone response elements' molecular and cellular endocrinology.”,Mol. and Cell. Endocrin., 139(1-2):25-35 (1998).
Desjarlais & Berg, “Length-Encoded Multiplex Binding Site Determination: Application to Zinc Finger Proteins,”PNAS 91:11099-11103 (1994).
Desjarlais & Berg, “Redesigning the DNA-binding specificity of a zinc finger protein: a data base-guided approach,”Proteins 12: 101-104 (1992).
Hall et al., “Functional interaction between the two zinc finger domains of the v-erb A oncoprotein”.Cell Growth and Differentation, 3:207-216 (1992).
Kim et al., “A novel member of the RING finger family KRIP-a associates with the KRAB-A transcriptional repressor domain of zinc-finger proteins,”PNAS93: 15299-15304 (1996).
Kim et al., “Design of TATA Box-Binding Protein/Zinc Finger Fusions for Targeted Regulation of Gene Expression,”PNAS94:3616-3620.
Klug, “Zinc Finger Peptides for the Regulation of Gene Expression,”J. Mol. Biol. 293:215-218 (1999).
Liu et al., “Design of Polydacty Zinc-Finger Proteins for Unique Addressing Within Complex Genomes,”PNAS 94:5525-5530 (1997).
Liu et al., “Regulation of an Endogenous Locus Using a Panel of Designed Zinc Finger Proteins Targeted to Accessible Chromatin Regions: Activation of Vascular Endothelial Growth Factor A,”Journal of Biological Chemistry 276(14):11323-11334 (2001).
Miller et al.,“Repetitive Zinc-Binding Domains in the Protein Transcription Factor IIIA fromXenopus Oocytesl ,”EMBO J. 4: 1609-1614 (1985).
Nolte et al., “Differing Roles for Zinc Fingers in DNA Recognition: Structure of a Six-Finger Transcription Factor IIIA Complex,”Proc. Natl. Acad. Sci. U.S.A. 95:2938-2943 (1998).
Pavletich, N.P. & Pabo, C.O., “Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers,”Science 261: 1701-1707 (1993).
Pavletich, N.P. & Pabo, C.O., “Zinc finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 A,”Science 252:809-814 (1991).
Pomerantz et al., “Structure-Based Design of a Dimeric Zinc Finger Protein,”Biochemistry 37(4):965-970 (1998).
Rhodes et al., “Zinc fingers,”Scientific American 268:56-65 (1993).
Scheinman et al., “Characterization of Mechanisms involved in transfrepression of NF-kappa B by activated blucocorticoid receptors”.Mol. Cell. Biol. ,15(2):943-953 (1995).
Zhang et al., “Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site. Activation of the Human Erythropoietin G ne,”J. Biol. Chem. 275:33850-33860 (2000).

Affiliated with

Also associated with

Rating

Cells for drug discovery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cells for drug discovery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cells for drug discovery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3626439