Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-01-31
2006-01-31
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S034000, C435S235100, C435S238000, C435S239000, C435S325000
Reexamination Certificate
active
06991899
ABSTRACT:
The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells which show increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious virions. The invention is suitable for use in culturing clinical influenza and parainfluenza virus isolates and for the production of influenza and parainfluenza virus for vaccine formulations, as antigen preparations for diagnostic applications, and for screening antiviral drugs.
REFERENCES:
patent: 5939253 (1999-08-01), Scholl et al.
patent: 6168915 (2001-01-01), Scholl et al.
patent: 6610474 (2003-08-01), Huang
patent: 2002/0082224 (2002-06-01), Jolly et al.
Huang and Turchek (2000) “Mink Lung Cells and Mixed Mink Lung and A549 Cells for Rapid Detection of Influenza Virus and Other Respiratory Viruses,” J. Clin. Microbiol. 38:422-423.
Schultz-Cherry et al., (1998) “Mink Lung Epithelial Cells: Unique Cell Lines that Supports Influenza A and B Virus Replication,” J. Clin. Microbiol. 36:3718-3720.
Steineke-Grober et al. (1992) “Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease,” EMBO J. 11:2407-2414.
Walker et al. (1994) “Sequence Specificity of Furin, a Proprotein-Processing Endoprotease, for the Hemagglutinin of a Virulent Avian Influenza Virus,” J. Virol. 68:1213-1218.
Morikawa et al. (1993) “Legitimate and Illegitimate Cleavage of Human Immunodeficiency Virus glycoproteins by Furin,” J. Virol. 67:3601-3604.
Hallenberger et al. (1992) “Inhibitor of furin-mediated cleavage activation of HIV-1 glycoprotein gp160,” Nature 360:358-361.
Watanbe et al. (1995) “Engineered Serine Protease Inhibitor Prevents Furin-Catalyzed Activation of the Fusion Glycoprotein and Production of Infectious Measles Virus,” J. Virol. 69:3206-3210.
Volchkov et al. (1998) “Processing of the Ebola virus glycoprotein by the proprotein convertase furin,” Proc. Natl. Acad. Sci. USA 95:5762-5767.
Ortmann et al. (1994) “Proteolytic Cleavage of Wild Type and Mutants of the F Protein of Human Parainfluenza Virus type 3 by Two Subtilisin-Like Endoproteases, Furin and Kex2,” J. Virol. 68:2772-2776.
van de Ven et al. (1990) “Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes,” Mol. Biol. Rep. 14:265-75.
Knaizeff et al. (1976) “Characteristics of Epithelial Cell Cultured from Feline Lung,” Lab. Invest. 5:495-500.
Milo et al. (1984) “Growth Characteristics, Morphology, and Phospholipid Composition of Human Type II Pulmonary Alveolar Cells Grown in a Collagen-Free Microenvironment,” In Vitro, 20:899-911.
Richards et al. (1987) “Isolation, Biochemical Characterization, and Culture of Lung Type II Cells of the Rat,” Lung 165:143-158.
Robinson et al. (1984) “Isolation and Culture of Human Alveolar Type II Epithelial Cells,” Am. Rev. Respir. Disease 130:1156-1160.
Palache et al. (1997) “Immunogenicity and Reactogenicity of Influenza Subunit Vaccines Produced in MDCK Cells or Fertilized Chicken Eggs,” J. Infect. Dis. 176(suppl. 1):S20-S23.
GenBank Accession No. X17094.
Dubois et al. (1995) “Processing of transforming growth factor beta 1 precursor by human furin covertase,” J. Biol. Chem. 270:10618-10624.
Shapiro et al. (1997) “Localization of Endogenous Furin in Cultured Cell Lines,” J. Histochem. & Cytochem. 45:3-12.
GenBank Accession No. A1344029.
Subbarao et al. (1998) “Characterization of an Avian Influenza A (H5Nl) Virus Isolated from a Child with a Fatal Respiratory Illness,” Science 279:393-396.
Huang et al. (2002) “Engineered BGMK Cells for Sensitive and Rapid Detection of Enteroviruses,” J. Clin. Microbiol. 40:366-371.
Hosaka et al. (1991) “Arg-X-Lys/Arg-Arg Motif as a Signal for Precursor Cleavage Catalyzed by Furin within the Constitutive Secretory Pathway,” J. Biol. Chem. 266:12127-12130.
Klimstra et al. (1999) “Furin Protease Cleavage Recognition Sequence of Sindbis Virus PE2 Can Mediate Virior Attachment to Cell Surface Heparan Sulfate,” J. Virology 73:6299-6306.
Moehring et al. (1993) “Expression of Mouse Furin in a Chinese Hamster Cell Resistant toPseudomonasExotoxin A and Viruses Complements the Genetic Lesion,” J. Biol. Chem. 268:2590-2594.
Ohnishi et al. (1994) “A Furin-Defective Cell Line Is Able to Process Correctly the gp160 of Human Immunodeficiency Virus Type 1,” J. Virol. 68:4075-4079.
Richt et al. (1998) “Processing of the Borna Disease Virus Glycoprotein gp94 by the Subtilisin-Like Endoprotease Furin,” J. Virol. 72:4528-4533.
Simmen et al. (1999) “Basolateral Sorting of Furin in MDCK Cells Requires a Phenylalanine-Isoleucine Motif Together with an Acidic Amino Acid Cluster,” Mol. & Cell. Biol. 19:3136-3144.
Stadler et al. (1997) “Proteolytic Activation of Tick-Borne Encephalitis Virus by Furin,” J. Virol. 71:8475-8481.
Medlen & Carroll LLP
Mosher Mary E.
University Hospitals of Cleveland
LandOfFree
Cells for detection of influenza and parainfluenza viruses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cells for detection of influenza and parainfluenza viruses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cells for detection of influenza and parainfluenza viruses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3536529