Cells encapsulated in alginate containing a high content of a- l

Details Cells encapsulated in alginate containing a high content of a- l Cells encapsulated in alginate containing a high content of a- l

1993-07-02

1995-10-17

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435182, 43524022, 424 937, C12N 1110, C12N 1104, C12N 500, A61K 3700

Patent

active

054590540

ABSTRACT:
Cells such as mammalian or genetically modified cells are encapsulated in high-G alginate that provokes reduced immune response during transplantation or implantation. The alginate contains greater than 50% .alpha.-L-guluronic acid and a minimal amount of mannuronic acid. The amount of .alpha.-L-guluronic acid is preferably at least 65% and more preferably at least 85%. Encapsulation is carried out by suspending cells in a solution of the high-G alginate, forming drops of the solution and contacting the drops with calcium ions to gel the alginate and form microcapsules containing the cells. The microcapsules may contain multiple layers with the high-G alginate preferably forming the outermost layer.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4407957 (1983-10-01), Lim
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4950600 (1990-08-01), Tanaka et al.

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