Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-06-07
2000-04-11
Schwartzman, Robert A.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4353723, A61K 4800, C12N 510
Patent
active
060485256
ABSTRACT:
A cell, particularly a hematopoietic cell population wherein the cells are trapped with respect to activation by an antigen to which the immune system of the host; (human or animal) is to be made tolerant. The cells contain a genetic sequence of which the expression product (e.g. HSV1--TK--) may, when its production is increased so that it is present in a sufficient quantity within said trapped cells, react in situ with a pharmaceutically active substance (e.g. acyclovir) to induce the destruction of the cells and of means (e.g. a promoter of an interleukin receptor controlling the expression of said genetic sequence) which are specifically induced by an activation signal provided by the antigen to the cells, to cause the aforesaid increased production. The production of drugs implementing the above mentioned principles in order to prevent host immune system dysfunctions which are natural (autoimmune diseases) or induced (grafts), is also described.
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Schwartzman Robert A.
Universite Pierre & Marie Curie
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