Cell wall mannoproteins and active epitopes from Candida...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds specifically-identified oligosaccharide structure

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S141100, C530S387500, C530S388100, C530S389100, C530S388500, C514S008100, C435S975000

Reexamination Certificate

active

07632502

ABSTRACT:
An isolated surface protein known as mp58 is provided from the yeastCandida albicanswhich has specific active peptide and carbohydrate regions and immunogenic epitopes therein and which elicits strong antibody responses during candidiasis. Antibodies raised from mp58 and the immunogenic regions and epitopes therein are also provided which can recognize the protein and its active regions and epitopes. The protein and antibodies of the present invention will thus be useful in methods of diagnosing, monitoring, treating or preventing infection ofC. albicansand other yeast, and can also provide the basis for the development of immunity-based prophylactic, therapeutic and diagnostic techniques for the identification and management of disease conditions such as candidiasis.

REFERENCES:
patent: WO 00/52053 (2000-09-01), None
The Webster's II New Riverside University Dictionary, The Riverside Publishing Company, p. 933, 1984.
Illustrated Stedman's Medical Dictionary, 24thEdition, Williams & Wilkins, Baltimore, 24thEdition, p. 707, 1982.
Barturen et al. Microbiology 1535-1543, 1995.
Bikandi et al. J. Dental Res. 79: 1439-1472, Jun. 2000.
Casanova et al. Infect. Immun. 60: 4221-4229, 1992.
Viudes et al., “Identification of Continuous B-Cell Epitopes on the Protein . . . ”, Infection and Immunity, May 2001, pp. 2909-2919, vol. 69, No. 5.
Lopez-Ribot et al., “Cloning of a cDNA fragment encoding part of the protein . . . ”, FEMS Microbiology Letters 157 (1997), pp. 273-278.
Sentandreu et al., “Cloning and Characterization of PRA1, a Gene Encoding a Novel . . . ”, Journal of Bacteriology, Jan. 1998, vol. 180, No. 2, pp. 282-289.
Lopez-Ribot et al., “Comparative Study of the C3d Receptor and 58-Kilodalton . . . ”, Infection and Immunity, Jun. 1995, vol. 63, No. 6, pp. 2126-2132.
Sepulveda et al., “Candida albicansfibrinogen binding mannoprotein: expression in clinical . . . ”, Internatl Microbiol (1998) 1:209-216.
Matthews et al “Antibodies AgainstCandida: Potential Therapeutics?” Sep. 1996, pp. 354-358, vol. 4, No. 9, Trends in Microbiology, Kidlington, Great Britain.
De Bernardis et al “Protective role of antimannan and anti-aspartyl porteinase antibodies in an experimental model ofCandida albicanvaginitis in rats” Aug. 1997, pp. 3399-3405, No. 8, Infection and Immunity.
Monteagudo et al “Tissue invasiveness and non-acidic pH in human candidiasis correlate with “in vitro” expression byCandida albicansof the carbohydrate epitope recognized bynew monoclonal antibody 1H4”, Jun. 2004, pp. 598-603, vol. 57, No. 6, Journal of Clinical Pathology.
Viudes Angel et al “The C-terminal antibody binding domain ofCandida albicanmp58 represents a protective epitope during candidiasis” Mar. 19, 2004, pp. 133-138, vol. 232, No. 2, FEMS Microbiology Letters.
Cassone et al “Production And Characterization Of A Monoclonal Antibody To A Cell-Surface Glucomannoprotein Constituent OfCandida-albicansAnd Other Pathogenic Candida-Spp”, 1988, pp. 233-238, vol. 27, No. 4, Journal of Medical Microbiology.
Yongmoon et al, “Biochemical Characterization OfCandida albicansEpitopes That Can Elicit Protective And Nonprotective Antibodies”, Oct. 1997, pp. 4100-4107, vol. 65, No. 10, Infection and Immunity, American Society for Microbiology, Washington, US.
Han et al, “Antibody Response That Protects Against Disseminated Candidiasis.” Jul. 1995, pp. 2714-2719, vol. 63, No. 7, Infection and Immunity.
Navarro et al, “Diagnosis Of Systemic Candidiasis By Enzyme Immunoassay Detection Of Specific Antibodies To Mycelial Phase Cell Wall And Cytoplasmic Candidal Antigens”, 1993, pp. 839-846, vol. 12, No. 11, European Journal of Clinical Microbiology & Infectious Disease, Springer, Wiesbaden, DE.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cell wall mannoproteins and active epitopes from Candida... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell wall mannoproteins and active epitopes from Candida..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell wall mannoproteins and active epitopes from Candida... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4141606

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.