Chemistry: molecular biology and microbiology – Vector – per se
Patent
1994-07-22
2000-11-14
Guzo, David
Chemistry: molecular biology and microbiology
Vector, per se
536 234, 536 2353, 536 2372, C12N 1586
Patent
active
061468851
ABSTRACT:
The present invention pertains to retroviral vector particles having target cell specificity which comprise a retroviral vector having an antigen binding site of an antibody fused to the envelope protein of the retroviral vector, wherein the antigen binding site of the antibody replaces the natural viral receptor binding site.
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Eliot Marshall, "Gene Therapy's Growing Pains", Science, vol. 269, Aug. 25, 1995, pp. 1050-1055.
Russell et al., "Retroviral Vectors Displaying Functional Antibody, Fragments", Nucleic Acids Res., vol. 21, No. 5, 1993, pp. 1081-1085.
Kewalramani, V.N., et al. "Spleen Necrosis Virus, an avian innunossupressive retrovirus, shares a receptor with the type D simian retroviruses", Journal of Virology, vol. 66, No. 5, May 1992, pp. 3026-3031.
Riley, S.C., et al. "Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes," Proceedings of the National Academy of Sciences of USA, vol. 83, No. 8, Apr. 1986, pp. 2589-2593.
Te-Hua, T.C., et al. "Cell targeting with retroviral vector particles containing antibody-envelope fusion proteins," Gene Therapy, vol. 1, No. 5, Sep. 1994, pp. 292-299.
Guzo David
University of Medicine and Dentistry of New Jersey
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