Cell type specific gene transfer using retroviral vectors contai

Details Cell type specific gene transfer using retroviral vectors contai Cell type specific gene transfer using retroviral vectors contai

1997-08-28

1999-02-09

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

5303873, G12N 1586, C07K 1646

Patent

active

058693319

ABSTRACT:
The present invention pertains to retroviral vector particles having target cell specificity which comprises a retroviral vector having a targeting peptide fused to the envelope protein of the retroviral vector to form a targeting envelope, wherein the targeting peptide replaces or disrupts the natural viral receptor binding site and the targeting peptide is the antigen binding site of an antibody, the receptor binding peptide of another virus, or is a peptide that specifically binds to a specific receptor of the target.

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Riley, S.C. et al. "Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes," Proceedings of the National Academy of Sciences of USA, vol. 83, No. 8, Apr. 1986, pp. 2589-2593.
Russell, S.J. et al. "Retroviral vectors displaying functional antibody fragments," Nucleic Acids Res. (1993), 21(5), pp. 1081-1085.
Te-Hua, T.C., et al. "Cell targeting with retroviral vector particles containing antibody-envelope fusion proteins," Gene Therapy, vol. 1, No. 5, Sep. 1994, pp. 292-299.
Marshall, "Gene Therapy's Growing Pains", Science, vol. 269, 25 Aug. 1995, pp. 1050-1055.
Russell et al., "Retrovial Vectors Displaying Fuctional Antibody Fragments", Nuclear Acids Res., vol. 21, No. 5, pp. 1081-1085, 1993.
A. Duatz Miller, "Human Gene Therapy Comes of Age", Nature, vol. 357, Jun. 1992, pp. 455-460.
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Weiss, In "RNA Tumor Viruses", Chapter 3, pp. 226-260, Weiss et al., Eds., Cold Spring Harbor Labortory, 1984.

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